Allergic diseases in children with otitis media with effusion
Allergic diseases in children with otitis media with effusion
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DOI：
10.1016/j.ijporl.2012.09.039
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发表时间：
2013-02-01
影响因子：
1.5
通讯作者：
Yeo, Seung Geun
中科院分区：
文献类型：
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作者：
Kwon, Chul;Lee, Ho Yun;Yeo, Seung Geun
目的：最近的研究表明，过敏性疾病可能与复发性渗出性中耳炎(OME)的发病有关。我们的目的是评估OME与过敏性疾病和其他类型疾病的关系。材料与方法：我们评估了2007年1月至2012年12月确诊的370例OME患者，并选择100例无OME病史但接受过血液检测和MAST-CLA(多重变态反应试验-化学发光法)检查的儿童作为对照组。结果：在变态反应性疾病中，单纯OME儿童变应性鼻炎的发生率(33.8%)显著高于非OME儿童(16.0%)(p<；0.05)。OME患者中腺样体肥大的比例也显著高于无OME患者(p<；0.05)，但扁桃体肥大的比例并不明显。评价OME患者中耳积液的特点，发现浆液性中耳积液186例，粘液性中耳积液129例，化脓性中耳积液55例。其中，变应性鼻炎75例(40.3%)，变应性鼻炎36例(27.9%)，变应性鼻炎14例(25.5%)，其中浆液组变应性鼻炎和哮喘的发生率显著高于粘液组(P<；0.05)。结论：儿童OME组变应性鼻炎的发生率明显高于无OME组，其他变态反应性疾病的发生率在两组间无显著差异。浆液性鼻炎患者发生变应性鼻炎和哮喘的可能性高于粘液性Mee患者。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
Objectives: Recent studies have shown that allergic diseases may be associated with the pathogenesis of recurrent otitis media with effusion (OME). We aimed to assess the relationship between OME and allergic diseases and other types of disease in children with OME. We also evaluated the between group differences in the characteristics of middle ear effusion.Materials and methods: We evaluated 370 patients diagnosed with OME between January 2007 and December 2012 and, as a control group, 100 children with no medical history of OME but who had undergone blood tests and MAST-CLA (multiple allergosorbent test - chemiluminescent assay) were selected.Result: Among the allergic diseases, the incidence of allergic rhinitis alone was significantly higher in children with OME (33.8%) than without OME (16.0%) (p < 0.05). The rate of adenoid, but not tonsil, hypertrophy was significantly greater in patients with than without OME also (p < 0.05). When we evaluated the characteristics of middle ear effusion (MEE) in patients with OME, we found that 186 had serous, 129 had mucous and 55 had purulent MEE. Of these patients, 75 (40.3%), 36 (27.9%) and 14 (25.5%), respectively, had allergic rhinitis and the rates of allergic rhinitis and asthma were significantly higher in the serous group than in the mucous group (p < 0.05).Conclusion: Allergic rhinitis was significantly more frequent among pediatric patients with than without OME, although the rates of other allergic diseases did not differ in these two groups. The likelihoods of allergic rhinitis and asthma were higher in patients with serous than with mucous MEE. (C) 2012 Elsevier Ireland Ltd. All rights reserved.