GABA-LIKE IMMUNOREACTIVITY IN THE VERTEBRATE RETINA - A SPECIES COMPARISON
GABA-LIKE IMMUNOREACTIVITY IN THE VERTEBRATE RETINA - A SPECIES COMPARISON
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DOI：
10.1016/0014-4835(86)90052-7
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发表时间：
1986-06-01
影响因子：
3.4
通讯作者：
STUDHOLME, KM
中科院分区：
文献类型：
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作者：
MOSINGER, JL;YAZULLA, S;STUDHOLME, KM
用与牛血清白蛋白偶联的γ-氨基丁酸(GABA)兔抗血清对人、猫、兔、鼠、鸡、龟、蛙、小狗和金鱼等9种动物的视网膜内含有GABA样免疫反应的神经元进行了定位。所有物种的视网膜在内核层的几组无长突细胞、节细胞层的细胞(可能包括移位的无长突细胞)、内网层和视神经纤维层的纤维中都有GABA样标记。在猫和所有非哺乳动物视网膜中均可见标记的水平细胞。在大鼠、兔、猫和人的视网膜中发现了标记的网状细胞。标记的双极细胞仅限于青蛙和泥巴狗的视网膜。抗-GABA的分布通常与抗谷氨酸脱羧酶和神经元[~3H]GABA摄取的分布相似，表明这些“GABA能”标记之间有很好的对应关系。然而，这些标记之间的几个显著差异也进行了讨论。
Rabbit antisera directed against .gamma.-amino butyric acid (GABA) conjugated to bovine serum albumin was used to localize neurons containing GABA-like immunoreactivity in the retinas of nine species of animals: human, cat, rabbit, rat, chicken, turtle, frog, mudpuppy and goldfish. The retinas of all species contained GABA-like labeling in several populations of amacrine cells in the inner nuclear layer, cells in the ganglion-cell layer that may include displaced amacrine cells and in fibers in the inner plexiform layer and in the optic nerve fiber layer. Labeled horizontal cells were found in cat and in all non-mammalian retinas. Labeled interplexiform cells were found in rat, rabbit, cat and human retinas. Labeled bipolar cells were restricted to frog and mudpuppy retinas. The distribution of anti-GABA is usually similar to that of anti-glutamic acid decarboxylase and neuronal [3H]GABA uptake, indicating good correspondence between these ''GABAergic'' markers. However, several significant differences among these markers are discussed.