Wnt Signaling from Development to Disease: Insights from Model Systems
Wnt Signaling from Development to Disease: Insights from Model Systems
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DOI：
10.1101/cshperspect.a002881
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发表时间：
2009-08-01
影响因子：
7.2
通讯作者：
Peifer, Mark
中科院分区：
文献类型：
--
作者：
Cadigan, Ken M.;Peifer, Mark
细胞粘附研究的早期惊喜之一是发现β-连环蛋白发挥双重作用，作为基于钙粘蛋白的细胞-细胞粘附连接的重要组成部分，也作为Wnt信号通路的关键调节效应子。在这里，我们回顾了我们目前的Wnt信号转导模型，并讨论了最近的工作如何使用模式生物推进了我们对Wnt信号转导在正常发育和疾病中所起作用的理解。这些数据有助于充实从细胞膜到细胞核的信号传导机制，揭示新的蛋白质参与者，并提供有关该途径已知组分的新信息。
One of the early surprises in the study of cell adhesion was the discovery that beta-catenin plays dual roles, serving as an essential component of cadherin-based cell-cell adherens junctions and also serving as the key regulated effector of the Wnt signaling pathway. Here, we review our current model of Wnt signaling and discuss how recent work using model organisms has advanced our understanding of the roles Wnt signaling plays in both normal development and in disease. These data help flesh out the mechanisms of signaling from the membrane to the nucleus, revealing new protein players and providing novel information about known components of the pathway.