Antioxidant and osteogenic properties of anodically oxidized titanium
Antioxidant and osteogenic properties of anodically oxidized titanium
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DOI：
10.1016/j.jmbbm.2012.01.016
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发表时间：
2012-09-01
影响因子：
3.9
通讯作者：
Miyazaki, Takashi
中科院分区：
文献类型：
--
作者：
Iwai-Yoshida, Misato;Shibata, Yo;Miyazaki, Takashi
在伤口愈合过程中，附着在植入物表面的细胞会受到氧化应激的影响。虽然钛及其合金是骨科和牙科植入物中最常用的生物材料之一，但钛表面没有抗氧化性能，生长在这些表面上的细胞可能会显示出永久性的氧化应激。本研究评估了氧化处理前后钛样品的抗氧化性和成骨性能。在热氧化的钛表面上观察到一层厚厚的金红石型二氧化钛薄膜，而在1MNa2HPO4中放电的阳极氧化的钛表面上形成无定形的锐钛矿型二氧化钛。在阳极氧化的钛上，对粘附性成骨细胞中还原型谷胱甘肽的耗竭产生了抵抗，这与抗氧化行为有关。与热氧化或未处理的钛相比，阳极氧化处理的钛实现了成骨基因的表达和矿化组织的纳米生物力学性能的增强。因此，在电解液中放电的阳极氧化有望成为钛植入体的一种有用的表面修饰。(C)2012爱思唯尔有限公司。保留所有权利。
Cells adhering onto implant surfaces are subjected to oxidative stress during wound healing processes. Although titanium and its alloys are among the most frequently used biomaterials in orthopedic and dental implants, titanium surfaces do not have antioxidant properties, and cells grown on these surfaces can show permanent oxidative stress. The present study assessed the antioxidant property and osteogenic properties of titanium samples with or without oxidation treatments. A thick rutile TiO2 film was observed on thermally oxidized titanium surfaces, while amorphous anatase TiO2 formed on anodically oxidized titanium surfaces prepared by discharging in 1 M Na2HPO4. A resistance to the depletion of reduced glutathione in adherent osteoblasts, which correlates with antioxidant behavior, occurred on anodically oxidized titanium. Enhanced osteogenic gene expressions and nano-biomechanical properties of mineralized tissue were achieved on anodically oxidized titanium, in comparison with thermally oxidized or untreated titanium. Thus, anodic oxidation by discharging in electrolyte is expected to be a useful surface modification for titanium implants. (c) 2012 Elsevier Ltd. All rights reserved.