A lipogenic effect in intact male hamsters infected with plerocercoids of the tapeworm, Spirometra mansonoides.
A lipogenic effect in intact male hamsters infected with plerocercoids of the tapeworm, Spirometra mansonoides.
复制标题
对感染绦虫 Spirometra mansonoides 的多尾蚴的完整雄性仓鼠具有脂肪生成作用。
DOI：
10.2307/3279573
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
R. Carroll
中科院分区：
文献类型：
--
作者：
C. Phares;R. Carroll
绦虫（Spirometra mansonoides）的Plerocercoids产生一种有效的生长刺激物质，该物质在几种哺乳动物中具有活性。虽然大多数的plerocercoid生长因子（PGF）的行动是类似的生长激素（GH），脂质代谢是一个领域，他们的行动是不一样的。这份报告表明，plerocercoid感染不仅刺激生长的完整的雄性仓鼠，但脂肪生成以及。通过附睾脂肪垫重量、血清甘油三酯、胆固醇和总脂质的增加证实了类尾蚴感染的脂肪生成效应。感染了plerocercoid的仓鼠的肝脏也比对照组有更多的胆固醇和脂质磷。使用[2- 14 C]乙酸盐的掺入研究表明，感染仓鼠在1小时后比对照组在其肝脏和血清中掺入了显著更高水平的放射性核素。类尾蚴感染的脂肪生成作用明显不同于报告的GH的脂解作用，并且[2- 14 C]乙酸盐掺入附睾脂肪垫的任何刺激的缺乏也不同于报告的胰岛素的急性作用。
Plerocercoids of the tapeworm, Spirometra mansonoides, produce a potent growth stimulating substance which is active in several species of mammals. While most of the actions of the plerocercoid growth factor (PGF) are similar to those of growth hormone (GH), lipid metabolism is one area where their actions are not alike. This report demonstrates that plerocercoid infection not only stimulates growth of intact male hamsters but is lipogenic as well. The lipogenic effects of plerocercoid infection were demonstrated by increases in epididymal fat pad weights, serum triglycerides, cholesterol, and total lipid. The livers of the plerocercoid-infected hamsters also had more cholesterol and more lipid phosphorus than controls. Incorporation studies using [2-14C]acetate showed that infected hamsters incorporated significantly higher levels of the radionuclide in their livers and serum after 1 hr than the controls. The lipogenic effect of plerocercoid infection is distinctly unlike the reported lipolytic action of GH and the lack of any stimulation of [2-14C]acetate incorporation into the epididymal fat pads is unlike the reported acute actions of insulin as well.