The PrEP Journey: Understanding How Internal Drivers and External Circumstances Impact The PrEP Trajectory of Adolescent Girls and Young Women in Cape Town, South Africa.

The PrEP Journey: Understanding How Internal Drivers and External Circumstances Impact The PrEP Trajectory of Adolescent Girls and Young Women in Cape Town, South Africa.
复制标题

DOI:
10.1007/s10461-020-03145-0
复制
发表时间:
2021-07
期刊:
影响因子:
4.4
通讯作者:
van der Straten A
van der Straten A
中科院分区:
医学2区
文献类型:
--
作者:
O'Rourke S;Hartmann M;Myers L;Lawrence N;Gill K;Morton JF;Celum CL;Bekker LG;van der Straten A

文献摘要

参考文献

被引文献

相似文献

尽管南非的少女和年轻女性(AGYW)感染艾滋病毒的风险很高,但她们在坚持PrEP方面面临着许多挑战。为了更好地了解AGYW的PrEP动机和影响PrEP依从性的因素,我们在一项为期12个月的前瞻性研究中对22名南非的AGYW进行了系列深度访谈。访谈探讨了PrEP使用的动机和最初经历、依从性模式、社会支持以及停止或坚持使用PrEP的原因。我们还评估了药物水平作为依从性的生物标志物;在第1、2、3、6和12个月收集干血点,评估细胞内替诺福韦二磷酸水平。最终用户旅程分析方法揭示了与使用行为和情感方面相关的主题,包括导致PrEP依从性轨迹不同的多层次因素。我们的研究结果强调了内部和外部动机是如何驱动PrEP使用的,以及如何处理积极的身份形成和挑战,这对于理解AGYW在PrEP旅程中的作用至关重要。
Despite high risk for HIV, South African adolescent girls and young women (AGYW) experience numerous challenges with adherence to PrEP. To better understand AGYW’s motivations for PrEP and factors that impact PrEP adherence, we conducted serial in-depth interviews with 22 South African AGYW during a 12 month prospective study. Interviews explored motivations and initial experiences of PrEP use, patterns of adherence, social support, and reasons for stopping or persisting with PrEP. We also assessed drug levels as a biomarker of adherence; dried blood spots were collected at months 1, 2, 3, 6, and 12 to assess intracellular tenofovir diphosphate levels. An end-user journey analytical approach revealed themes related to behavioral and emotional aspects of use, including multilevel factors leading to divergent PrEP adherence trajectories. Our findings highlight how internal versus external motivations drive PrEP use, as well as how positive identity formation and challenges are handled, which are essential to understand AGYW in their PrEP journeys.
DOI: 10.1097/qai.0000000000000172
发表时间: 2014-07-01
期刊: Journal of acquired immune deficiency syndromes (1999)
影响因子: --
作者:
Donnell D;Baeten JM;Bumpus NN;Brantley J;Bangsberg DR;Haberer JE;Mujugira A;Mugo N;Ndase P;Hendrix C;Celum C
通讯作者: Celum C
DOI: 10.1016/s0140-6736(19)31288-7
发表时间: 2019-07-27
期刊: LANCET
影响因子: 168.9
作者:
Baeten, Jared M.;Donnell, Deborah;Stringer, Jeffrey
通讯作者: Stringer, Jeffrey
DOI: 10.1097/qai.0000000000000141
发表时间: 2014-06-01
影响因子: 3.6
作者:
Ndase, Patrick;Celum, Connie;Baeten, Jared M.
通讯作者: Baeten, Jared M.
DOI: 10.1002/jia2.25636
发表时间: 2020-11
影响因子: 6
作者:
Celum CL;Gill K;Morton JF;Stein G;Myers L;Thomas KK;McConnell M;van der Straten A;Baeten JM;Duyver M;Mendel E;Naidoo K;Dallimore J;Wiesner L;Bekker LG
通讯作者: Bekker LG
DOI: 10.1002/jia2.25298
发表时间: 2019-07-01
影响因子: 6
作者:
Celum, Connie L.;Delany-Moretlwe, Sinead;Bekker, Linda-Gail
通讯作者: Bekker, Linda-Gail