The PrEP Journey: Understanding How Internal Drivers and External Circumstances Impact The PrEP Trajectory of Adolescent Girls and Young Women in Cape Town, South Africa.
The PrEP Journey: Understanding How Internal Drivers and External Circumstances Impact The PrEP Trajectory of Adolescent Girls and Young Women in Cape Town, South Africa.
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DOI:
10.1007/s10461-020-03145-0
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发表时间:
2021-07
影响因子:
4.4
通讯作者:
van der Straten A
中科院分区:
文献类型:
--
作者:
O'Rourke S;Hartmann M;Myers L;Lawrence N;Gill K;Morton JF;Celum CL;Bekker LG;van der Straten A
Despite high risk for HIV, South African adolescent girls and young women (AGYW) experience numerous challenges with adherence to PrEP. To better understand AGYW’s motivations for PrEP and factors that impact PrEP adherence, we conducted serial in-depth interviews with 22 South African AGYW during a 12 month prospective study. Interviews explored motivations and initial experiences of PrEP use, patterns of adherence, social support, and reasons for stopping or persisting with PrEP. We also assessed drug levels as a biomarker of adherence; dried blood spots were collected at months 1, 2, 3, 6, and 12 to assess intracellular tenofovir diphosphate levels. An end-user journey analytical approach revealed themes related to behavioral and emotional aspects of use, including multilevel factors leading to divergent PrEP adherence trajectories. Our findings highlight how internal versus external motivations drive PrEP use, as well as how positive identity formation and challenges are handled, which are essential to understand AGYW in their PrEP journeys.
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DOI:
10.1097/qai.0000000000000172
发表时间:
2014-07-01
期刊:
Journal of acquired immune deficiency syndromes (1999)
影响因子:
--
作者:
Donnell D;Baeten JM;Bumpus NN;Brantley J;Bangsberg DR;Haberer JE;Mujugira A;Mugo N;Ndase P;Hendrix C;Celum C
通讯作者:
Celum C
影响因子:
168.9
作者:
Baeten, Jared M.;Donnell, Deborah;Stringer, Jeffrey
通讯作者:
Stringer, Jeffrey
DOI:
10.1097/qai.0000000000000141
发表时间:
2014-06-01
影响因子:
3.6
作者:
Ndase, Patrick;Celum, Connie;Baeten, Jared M.
通讯作者:
Baeten, Jared M.
影响因子:
6
作者:
Celum CL;Gill K;Morton JF;Stein G;Myers L;Thomas KK;McConnell M;van der Straten A;Baeten JM;Duyver M;Mendel E;Naidoo K;Dallimore J;Wiesner L;Bekker LG
通讯作者:
Bekker LG
影响因子:
6
作者:
Celum, Connie L.;Delany-Moretlwe, Sinead;Bekker, Linda-Gail
通讯作者:
Bekker, Linda-Gail