CLONING OF A RAB3 ISOTYPE PREDOMINATELY EXPRESSED IN ADIPOCYTES
CLONING OF A RAB3 ISOTYPE PREDOMINATELY EXPRESSED IN ADIPOCYTES
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DOI：
10.1073/pnas.89.11.5049
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发表时间：
1992-06-01
影响因子：
11.1
通讯作者：
LODISH, HF
中科院分区：
文献类型：
--
作者：
BALDINI, G;HOHL, T;LODISH, HF
我们分离出了 Rab3D 的 cDNA，Rab3D 是小分子量 GTP 结合蛋白家族的另一个成员。 Rab3D 信息在小鼠脂肪细胞中丰富。它在 3T3-L1 细胞分化为脂肪细胞的过程中增加，与胰岛素敏感的葡萄糖转运蛋白 GLUT4 的出现时间一致。 Rab3D 是 Rab3A 的密切同源物，Rab3A 存在于神经分泌囊泡的细胞质表面，可能参与其分泌调节。由于我们之前的工作表明，在透化脂肪细胞中，不可水解的 GTP 类似物模拟胰岛素触发含有 GLUT4 的囊泡的胞吐作用，因此 Rab3D 可能参与胰岛素诱导的脂肪细胞中含有 GLUT4 的囊泡的胞吐作用。
We have isolated the cDNA for Rab3D, an additional member of the small molecular weight GTP-binding protein family. Rab3D message is abundant in mouse adipocytes. It is increased during differentiation of 3T3-L1 cells into adipocytes, temporally coincident with the appearance of the insulin-sensitive glucose transporter GLUT4. Rab3D is a close homolog of Rab3A, which is found on the cytoplasmic surface of neurosecretory vesicles and which may be involved in their regulated secretion. Since our previous work showed that in permeabilized adipocytes nonhydrolyzable GTP analogs mimic insulin in triggering exocytosis of GLUT4-containing vesicles, Rab3D may be involved in the insulin-induced exocytosis of GLUT4-containing vesicles in adipocytes.