Right hemisphere activation in recovery from aphasia -: Lesion effect or function recruitment?
Right hemisphere activation in recovery from aphasia -: Lesion effect or function recruitment?
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DOI：
10.1212/01.wnl.0000287115.85956.87
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发表时间：
2008-01-22
期刊：
影响因子：
9.9
通讯作者：
Cardebat, D.
中科院分区：
文献类型：
--
作者：
Raboyeau, G.;De Boissezon, X.;Cardebat, D.
背景资料：一些神经影像学研究表明，血管性失语症患者的右半球特定区域可以补偿左半球病变引起的功能障碍。特别是，右下额叶皮质可能参与词汇检索的患者提出左侧病变涉及homologous area.Objective：解决是否参与右下额叶皮质是唯一的恢复失语症患者或目前也在其他情况下丰富的词汇能力，即，方法：10名中风后失语症患者经历单词查找困难进行了强化训练，检索对象名称在法国超过4周的时间。20名健康受试者接受了类似的训练，以西班牙语或英语命名这些项目，即，他们在学校学过但没有掌握的外语。与失语症患者类似，健康受试者必须对长期习得但已遗忘的单词进行语音/音韵表征。脑活动的变化进行了评估，在两个H-2 O-15 PET会议涉及图片命名的任务，进行了之前和之后的training.Results：可比的训练后的性能和变化的区域脑血流，主要包括右岛和额下区被发现在两组。我们的研究结果表明，在失语症恢复过程中观察到的右侧区域活动增强不仅仅是左侧区域受损的结果，在对照组中也观察到了与词汇学习相关的神经元。
Background: Some neuroimaging studies have suggested that specific right hemispheric regions can compensate deficits induced by left hemispheric lesions in vascular aphasia. In particular, the right inferior frontal cortex might take part in lexical retrieval in patients presenting left-sided lesions involving the homologous area.Objective: To address whether the involvement of the right inferior frontal cortex is either unique to recovering aphasic patients or present also in other circumstances of enrichment of lexical abilities, i.e., in non-brain-damaged subjects over learning of new vocabulary.Methods: Ten post-stroke aphasic patients experiencing word finding difficulties were intensively trained to retrieve object names in French over a 4-week period. Twenty healthy subjects were similarly trained to name these items in either Spanish or English, i.e., foreign languages that they learned at school but did not master. By analogy to aphasic patients, healthy subjects had to work out the phonetic/phonologic representations of long-acquired but forgotten words. Brain activity changes were assessed in two H-2 O-15 PET sessions involving picture naming tasks that were performed before and after training.Results: Comparable post-training performance and changes in regional cerebral blood flow including mainly the right insular and inferior frontal regions were found in both groups.Conclusion: Our results suggest that enhanced activities in right-sided areas observed in recovering aphasia is not the mere consequence of damage to left-sided homologous areas and could reflect the neural correlates of lexical learning also observed in control subjects.