The intersecting pandemics of tuberculosis and COVID-19: population-level and patient-level impact, clinical presentation, and corrective interventions.
The intersecting pandemics of tuberculosis and COVID-19: population-level and patient-level impact, clinical presentation, and corrective interventions.
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结核病和COVID-19的交叉流行病：人口水平和患者水平的影响，临床表现和纠正干预措施。
DOI：
10.1016/s2213-2600(22)00092-3
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发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
Pai M
中科院分区：
文献类型：
--
作者：
Dheda K;Perumal T;Moultrie H;Perumal R;Esmail A;Scott AJ;Udwadia Z;Chang KC;Peter J;Pooran A;von Delft A;von Delft D;Martinson N;Loveday M;Charalambous S;Kachingwe E;Jassat W;Cohen C;Tempia S;Fennelly K;Pai M
全球结核病负担依然沉重，每年新增患者1 000多万人。尽管如此，结核病发病率在过去十年中缓慢下降，死亡率随之下降了近三分之一。这一积极趋势因COVID-19大流行而突然逆转，导致世界许多地区的结核病检测和病例通报大幅减少，相关死亡率增加，使全球结核病控制倒退约10年。在这里，我们考虑了结核病和COVID-19流行病之间的交叉点，确定了可以采取的广泛方法，以扭转COVID-19对结核病控制的破坏性影响。我们回顾了COVID-19在人群水平对结核病病例发现、发病率和死亡率的影响，以及患者水平的影响，包括对疾病的易感性、临床表现、诊断、管理和预后。我们提出策略以扭转或减轻COVID-19的有害影响，并恢复结核病服务。最后，我们强调研究的优先事项和重大挑战和争议，需要加以解决，以恢复和推进全球应对结核病。
The global tuberculosis burden remains substantial, with more than 10 million people newly ill per year. Nevertheless, tuberculosis incidence has slowly declined over the past decade, and mortality has decreased by almost a third in tandem. This positive trend was abruptly reversed by the COVID-19 pandemic, which in many parts of the world has resulted in a substantial reduction in tuberculosis testing and case notifications, with an associated increase in mortality, taking global tuberculosis control back by roughly 10 years. Here, we consider points of intersection between the tuberculosis and COVID-19 pandemics, identifying wide-ranging approaches that could be taken to reverse the devastating effects of COVID-19 on tuberculosis control. We review the impact of COVID-19 at the population level on tuberculosis case detection, morbidity and mortality, and the patient-level impact, including susceptibility to disease, clinical presentation, diagnosis, management, and prognosis. We propose strategies to reverse or mitigate the deleterious effects of COVID-19 and restore tuberculosis services. Finally, we highlight research priorities and major challenges and controversies that need to be addressed to restore and advance the global response to tuberculosis.
影响因子：
3.7
作者：
Peter JG;Theron G;Dheda K
通讯作者：
Dheda K