Preserved endothelium-independent vascular function with aging in men and women: evidence from the peripheral and cerebral vasculature.
Preserved endothelium-independent vascular function with aging in men and women: evidence from the peripheral and cerebral vasculature.
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随着男性和女性衰老，保留内皮依赖性血管功能：来自外周和脑血管系统的证据。
DOI：
10.1152/japplphysiol.00571.2022
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Richardson,RussellS
中科院分区：
文献类型：
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作者：
Shields,KatherineL;Jarrett,CatherineL;Bisconti,AngelaV;Park,SoungHun;Craig,JesseC;Broxterman,RyanM;Richardson,RussellS
在外周和脑血管系统中，年龄和性别对血管平滑肌细胞（VSMC）的内皮非依赖性功能能力的影响还不清楚，也不知道这些血管床中的VSMC功能是否相互反映。因此，非内皮依赖性扩张，在两个管道（Δ直径）和微血管（Δ血管传导性，VC）水平，由舌下硝酸甘油引起使用多普勒超声在20名年轻人[23 ± 4岁，10名男性（YM）/10名女性（YF）]和21名相对健康的老年人[69 ± 5岁，11名男性（OM）/10名女性（OF）]。在PA中，与零相比，NTG在所有组中均显著增加直径（YM：0.29 ± 0.13，YF：0.35 ± 0.26，OM：0.30 ± 0.18，OF：0.31 ± 0.14 mm），而对照组无此变化。VC的增加仅在OF中达到显著性（0.22 ± 0.31 mL/min/mmHg）。在大脑中动脉，与零相比，NTG在所有组中均显著增加直径和VC（YM：0.89 ± 0.30，1.06 ± 1.28; YF：0.97 ± 0.31，1.84 ± 1.07; OM：0.90 ± 0.42，0.72 ± 0.99; OF：0.74 ± 0.32，1.19 ± 1.18 mm和mL/min/mmHg），而对照组则无。NTG诱导的PA和MCA扩张和VC均无年龄或性别差异或年龄性别相互作用。此外，PA和MCA扩张与VC对NTG的反应在年龄、性别或所有受试者分组时均不相关（r = 0.04- 0.44，P> 0.05）。因此，外周和脑内皮非依赖性VSMC功能似乎不受年龄或性别的影响，其中一个血管床中VSMC功能的变化不会反映在另一个血管床中。新&值得注意的是，为了自信地解释外周和脑血管功能障碍，有必要清楚地了解不同年龄和性别的VSMC的内皮非依赖性功能。通过舌下含服硝酸甘油评估内皮非依赖性血管扩张，外周（腘动脉）和脑循环（大脑中动脉）中的内皮非依赖性VSMC功能没有因年龄或性别而不同。此外，在这些血管床之一的内皮非依赖性VSMC功能不反映在其他。
In the peripheral and cerebral vasculature, the impact of aging and sex on the endothelial-independent functional capacity of vascular smooth muscle cells (VSMCs) is not well understood, nor is it known whether such VSMC functions in these vascular beds reflect one another. Therefore, endothelium-independent dilation, at both the conduit (Δ diameter) and microvascular (Δ vascular conductance, VC) level, elicited by sublingual nitroglycerin (NTG, 0.8 mg of Nitrostat), compared with sham-delivery (control), was assessed using Doppler ultrasound in the popliteal (PA) and middle cerebral (MCA) artery of 20 young [23 ± 4 yr, 10 males (YM)/10 females (YF)] and 21 old [69 ± 5 yr, 11 males (OM)/10 females (OF)] relatively healthy adults. In the PA, compared with zero, NTG significantly increased diameter in all groups (YM: 0.29 ± 0.13, YF: 0.35 ± 0.26, OM: 0.30 ± 0.18, OF: 0.31 ± 0.14 mm), while control did not. The increase in VC only achieved significance in the OF (0.22 ± 0.31 mL/min/mmHg). In the MCA, compared with zero, NTG significantly increased diameter and VC in all groups (YM: 0.89 ± 0.30, 1.06 ± 1.28; YF: 0.97 ± 0.31, 1.84 ± 1.07; OM: 0.90 ± 0.42, 0.72 ± 0.99; OF: 0.74 ± 0.32, 1.19 ± 1.18, mm and mL/min/mmHg, respectively), while control did not. There were no age or sex differences or age-by-sex interactions for both the NTG-induced PA and MCA dilation and VC. In addition, PA and MCA dilation and VC responses to NTG were not related when grouped by age, sex, or as all subjects (r = 0.04–0.44,P> 0.05). Thus, peripheral and cerebral endothelial-independent VSMC function appears to be unaffected by age or sex, and variations in such VSMC function in one of these vascular beds are not reflected in the other.NEW & NOTEWORTHYTo confidently explain peripheral and cerebral vascular dysfunction, it is essential to have a clear understanding of the endothelial-independent function of VSMCs across age and sex. By assessing endothelium-independent dilation using sublingual nitroglycerin, endothelial-independent VSMC function in the periphery (popliteal artery), and in the cerebral circulation (middle cerebral artery), was not different due to age or sex. In addition, endothelial-independent VSMC function in one of these vascular beds is not reflected in the other.