Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma
Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma
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DOI：
10.1038/modpathol.3800967
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发表时间：
2008-01-01
期刊：
影响因子：
7.5
通讯作者：
Martignoni, Guido
中科院分区：
文献类型：
--
作者：
Brunelli, Matteo;Eccher, Albino;Martignoni, Guido
染色体9p的丢失与肾细胞癌的进展有关。我们评估了73例不同分期、大小、分级、坏死（SSIGN）评分的肾透明细胞癌患者染色体9p缺失的荧光原位杂交分析的临床应用价值。13例肿瘤（18%）出现染色体9p缺失。无9p染色体丢失的患者的5年肿瘤特异性生存率为88%，而有9p染色体丢失的患者的5年肿瘤特异性生存率为43%（P < 0.001）。在单变量分析中，根据2002年TNM分期系统，原发肿瘤的局部扩展，淋巴结受累，远处转移的存在和SSIGN评分是预测癌症特异性生存的其他变量。在多因素分析中，染色体9p丢失是独立的预后因素。我们的数据表明，通过透明细胞肾细胞癌的荧光原位杂交分析检测染色体9p丢失，除了目前肾细胞癌预测模型（如SSIGN评分）中包含的病理因素外，还增加了预后信息。
Loss of chromosome 9p has been implicated in the progression of renal cell carcinoma. We evaluated the clinical utility of fluorescence in situ hybridization analysis of loss of chromosome 9p in 73 patients with clear cell renal cell carcinomas with varied stage, size, grade, necrosis (SSIGN) scores. Loss of chromosome 9p was observed in 13 tumors (18%). The 5-year cancer-specific survival of patients without loss of chromosome 9p was 88% and was 43% in those with loss of chromosome 9p (P < 0.001). Local extension of the primary tumor according to the 2002 TNM staging system, lymph node involvement, the presence of distant metastases, and the SSIGN score were the other variables that predicted cancer-specific survival in univariate analysis. Loss of chromosome 9p was an independent prognostic factor in multivariate analysis. Our data indicate that the detection of chromosome 9p loss by fluorescence in situ hybridization analysis of clear cell renal cell carcinoma adds prognostic information beyond the pathological factors included in the current predictive models for renal cell carcinoma, such as SSIGN score.