Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuroexcitotoxicity: Potential therapeutic application for treatment of gliomas
Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuroexcitotoxicity: Potential therapeutic application for treatment of gliomas
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DOI：
10.1215/15228517-2007-051
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发表时间：
2008-04-01
期刊：
影响因子：
15.9
通讯作者：
Wang, Jia-Yi
中科院分区：
文献类型：
--
作者：
Fu, Yu-Show;Lin, Yen-Yang;Wang, Jia-Yi
我们测试了草药提取物2，3，5，6-川芎嗪(TMP)对胶质瘤细胞系和移植到大鼠脑内的胶质瘤的可能治疗效果。在培养的胶质瘤细胞中，50mU的TMP能显著抑制谷氨酸诱导的细胞内钙的升高。然而，显著的细胞损伤(30%)和增殖抑制(10%)只发生在较高的浓度(200-400微米)。与单独培养相比，胶质瘤联合培养可导致明显的神经元损伤和更高的细胞增殖(140%)。低浓度的TMP(
We tested the herbal extract 2,3,5,6-tetramethylpyrazine (TMP) for possible therapeutic efficacy against a glioma cell line and against gliomas transplanted into rat brains. In the cultured glioma cells, 50 mu M TMP significantly inhibited glutamate-induced increase in intracellular calcium. Significant cell damage (30%) and proliferation suppression (10%), however, occurred only at higher concentrations (200-400 mu M). Gliomaneuronal co-culturing resulted in significant neuronal damage and higher proliferation of the glioma cells (140%) compared with single cultures. Low concentrations of TMP (