Piracetam improves activated blood flow and facilitates rehabilitation of poststroke aphasic patients
Piracetam improves activated blood flow and facilitates rehabilitation of poststroke aphasic patients
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DOI：
10.1161/01.str.31.9.2112
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发表时间：
2000-09-01
期刊：
影响因子：
8.3
通讯作者：
Heiss, WD
中科院分区：
文献类型：
--
作者：
Kessler, J;Thiel, A;Heiss, WD
背景和目的-在一项前瞻性、双盲、安慰剂对照研究中，研究吡拉西坦是否能改善卒中后失语症患者的语言恢复，通过神经心理学测试和激活PET测量脑血流量进行评估。方法-24例卒中失语症患者随机分为2组：12例患者接受2400 mg吡拉西坦每日2次，12例安慰剂。在6周的治疗期之前和结束时，两组都接受了强化的语言治疗，患者进行了神经心理学检查，并在休息时和激活时用单词重复任务进行了H（2）（15）O PET研究。血流量进行了分析，在14个语言激活的大脑区域定义的重建表面视图从MRI共注册的PET图像，结果治疗前，两组在语言任务的性能和失语症的类型和严重程度是可比的。吡拉西坦组激活效应的增加显著高于对照组（P
Background and Purpose-In a prospective, double-blind, placebo-controlled study, it was investigated whether piracetam improves language recovery in poststroke aphasia assessed by neuropsychological tests and activation PET measurement of cerebral blood flow.Methods-Twenty-four stroke patients with aphasia were randomly allocated to 2 groups: 12 patients received 2400 mg piracetam twice daily, 12 placebo. Before and at the end of the 6-week treatment period in which both groups received intensive speech therapy, the patients were examined neuropsychologically and studied with H(2)(15)O PET at rest and during activation with a word-repetition task. Blood flow was analyzed in 14 language-activated brain regions defined on reconstructed surface views from MRI coregistered to the PET images,Results-Before treatment, both groups were comparable with respect to performance in language tasks and to type and severity of aphasia. In the piracetam group, increase of activation effect was significantly higher (P