Targeting the DNA Damage Response for Cancer Therapy.
Targeting the DNA Damage Response for Cancer Therapy.
复制标题
针对癌症治疗的 DNA 损伤反应。
DOI：
10.3390/ijms242115907
复制
发表时间：
2023-11-02
影响因子：
5.6
通讯作者：
Ba, Xueqing
中科院分区：
文献类型：
--
作者：
Wang, Ruoxi;Sun, Yating;Li, Chunshuang;Xue, Yaoyao;Ba, Xueqing
在长期的进化过程中，细胞已经发展出复杂的防御机制来应对DNA损伤;这些机制在维持基因组稳定性方面发挥着关键作用。DNA损伤反应途径中的缺陷可以引起各种疾病，包括癌症。DNA损伤反应（DDR）系统在保护基因组稳定性方面起着重要作用。DNA损伤的积累和DDR功能的减弱都促进了肿瘤的发生和发展。同时，它们为癌症治疗提供了机会和靶点。本文主要阐述了DNA损伤修复途径以及靶向这些途径中的关键蛋白用于癌症治疗的进展。其中，聚腺苷二磷酸核糖聚合酶1（poly（ADP-ribose）polymerase 1，PARP 1）在DDR中起着至关重要的作用，以PARP 1为靶点的抑制剂在抗癌研究中受到广泛关注。通过深入研究DNA损伤和修复领域，我们渴望探索更精确和有效的癌症治疗策略，并寻求新的干预途径。
Over the course of long-term evolution, cells have developed intricate defense mechanisms in response to DNA damage; these mechanisms play a pivotal role in maintaining genomic stability. Defects in the DNA damage response pathways can give rise to various diseases, including cancer. The DNA damage response (DDR) system is instrumental in safeguarding genomic stability. The accumulation of DNA damage and the weakening of DDR function both promote the initiation and progression of tumors. Simultaneously, they offer opportunities and targets for cancer therapeutics. This article primarily elucidates the DNA damage repair pathways and the progress made in targeting key proteins within these pathways for cancer treatment. Among them, poly (ADP-ribose) polymerase 1 (PARP1) plays a crucial role in DDR, and inhibitors targeting PARP1 have garnered extensive attention in anticancer research. By delving into the realms of DNA damage and repair, we aspire to explore more precise and effective strategies for cancer therapy and to seek novel avenues for intervention.
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影响因子：
5.7
作者：
Batey MA;Zhao Y;Kyle S;Richardson C;Slade A;Martin NM;Lau A;Newell DR;Curtin NJ
通讯作者：
Curtin NJ
影响因子：
3.5
作者：
Feng, Wanjuan;Smith, Chelsea M.;Gupta, Gaorav P.
通讯作者：
Gupta, Gaorav P.
影响因子：
2.1
作者：
Black, Jennifer O.
通讯作者：
Black, Jennifer O.
影响因子：
16
作者：
Collis, Spencer J.;Ciccia, Alberto;Boulton, Simon J.
通讯作者：
Boulton, Simon J.
影响因子：
5.2
作者：
Barcellini A;Loap P;Murata K;Villa R;Kirova Y;Okonogi N;Orlandi E
通讯作者：
Orlandi E