Attenuation of 8-OH-DPAT induced feeding after lesions of the area postrema/immediately adjacent nucleus of the solitary tract.
Attenuation of 8-OH-DPAT induced feeding after lesions of the area postrema/immediately adjacent nucleus of the solitary tract.
复制标题
孤束后区/紧邻核损伤后 8-OH-DPAT 诱导的摄食减弱。
DOI：
10.1016/0006-8993(93)90973-q
复制
发表时间：
1993
期刊：
影响因子：
2.9
通讯作者：
Power,JD
中科院分区：
文献类型：
--
作者：
Edwards,GL;Power,JD
在未受损伤的对照大鼠中，经过几次诱导进食的操作后，孤立束后/紧邻核区域损伤（AP/ mnts损伤）的大鼠的进食反应减弱。在这项研究中，我们检测了AP/ mnts病变大鼠在接受5- ht1拮抗剂8-OH-DPAT治疗后的摄食反应。AP/ mnts病变大鼠在8-OH-DPAT刺激完整大鼠的食物摄入剂量后，其食物摄入量没有增加。这些数据表明，在AP/ mnts病变大鼠中观察到的一些氧刺激治疗后，血清素功能的改变可能有助于摄食的衰减。
Rats with lesions of the area postrema/immediately adjacent nucleus of the solitary tract (AP/mNTS-lesions) have an attenuated feeding response after several manipulations that induce food intake in intact control rats. In this study we examined the ingestive response of rats with AP/mNTS-lesions after treatment with 8-OH-DPAT, a 5-HT1Aagonist. Rats with AP/mNTS-lesions failed to increase their food intake after treatment with 8-OH-DPAT at doses that stimulated food intake in intact rats. These data suggest that altered serotonergic function may contribute to the attenuation of feeding observed in rats with AP/mNTS-lesions after treatment with some orexigenic stimuli.