Aging affects the proportions of T and B cells in a group of elderly men in a developing country-a pilot study from Pakistan
Aging affects the proportions of T and B cells in a group of elderly men in a developing country-a pilot study from Pakistan
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DOI：
10.1007/s11357-012-9455-1
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发表时间：
2013-10-01
期刊：
影响因子：
--
通讯作者：
Pawelec, Graham
中科院分区：
文献类型：
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作者：
Alam, Iftikhar;Goldeck, David;Pawelec, Graham
老年人和年轻人的免疫状态不同，但发展中国家和工业化国家与年龄相关的差异是否相似尚不清楚。为了解决这个问题，外周血免疫细胞表型分析多色流式细胞术在50名年轻人和50名老年男性在巴基斯坦农村地区的试点研究。作为一个群体，老年人的CD4：CD8比率显著低于年轻人，CD8+幼稚T细胞的百分比较低，晚期分化记忆细胞的百分比显著高于年轻人。在B细胞或NK细胞中未观察到年龄相关差异。CD8+细胞占CD3+ T细胞的百分比与血浆CRP水平呈正相关，但与其他因素无关。我们的结论是，年轻和老年巴基斯坦男性的外周免疫细胞表型之间存在差异，这些似乎与工业化国家中更广泛记录的表型大致相似，尽管这些人群中存在显著的社会，营养和许多其他差异。
Immune status is different in the elderly and the young, but whether age-associated differences are similar in developing and industrialized countries is unclear. To approach this question, peripheral blood immune cell phenotypes were analyzed by polychromatic flow cytometry in 50 young and 50 elderly men in a pilot study in a rural area of Pakistan. As a group, the elderly had a significantly lower CD4:CD8 ratio, a lower percentage of CD8+ na < ve T cells, and significantly higher percentage of late-differentiated memory cells than the young. No age-associated differences were seen in B cells or NK cells. CD8+ cells as a percentage of CD3+ T cells were positively associated with plasma CRP levels but not other factors. We conclude that there are differences between the peripheral immune cell phenotypes of young and elderly Pakistani men and that these seem broadly similar to those more extensively documented in industrialized countries, despite the marked societal, nutritional, and many other differences in these populations.