Normal human intestinal B lymphocytes. Increased activation compared with peripheral blood.
Normal human intestinal B lymphocytes. Increased activation compared with peripheral blood.
复制标题
正常人肠道B淋巴细胞。
DOI：
10.1172/jci114088
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
MacDermott,RP
中科院分区：
文献类型：
--
作者：
Peters,MG;Secrist,H;Anders,KR;Nash,GS;Rich,SR;MacDermott,RP
本文研究了从移植供者体内获取的正常人肠道单个核细胞的活化状态。与PBMC相比，新鲜分离的肠道单个核细胞在B和T淋巴细胞上均表达更多的细胞表面活化抗原。肠道单个核细胞分离后即刻含有大量免疫球蛋白分泌细胞。这一群体包括CD5阳性的B细胞，它们主要分泌IgA。来自大肠的细胞始终显示出比来自小肠的细胞更多的IgA分泌细胞。因此，与PBMC相比，肠道B细胞在体内被显著激活，这种激活增加与自发抗体分泌的增加相关。来自大肠的B细胞比来自小肠的细胞更活跃，分泌更多的抗体。肠道固有层淋巴小室表现出高度的激活状态，这可能是其在粘膜防御中的独特作用的重要原因。
The state of activation of normal human intestinal mononuclear cells obtained from transplant donors was studied. Compared with PBMC, freshly isolated intestinal mononuclear cells expressed significantly more cell surface activation antigens on both B and T lymphocytes. Intestinal mononuclear cells contained significant numbers of immunoglobulin secreting cells immediately after cell separation. This population included CD5-positive B cells that secreted predominantly IgA. Cells from the large bowel consistently revealed higher numbers of IgA secreting cells than cells from the small bowel. Thus, intestinal B cells are markedly activated in vivo compared with PBMC and this increased activation correlates with increased spontaneous antibody secretion. B cells from the large intestine are more highly activated and secrete more antibody than do cells from the small intestine. The intestinal lamina propria lymphoid compartment exhibits a heightened state of activation that may be important for its distinct role in mucosal defense.Images