A CHOICE PROCEDURE TO ASSESS THE AVERSIVE EFFECTS OF DRUGS IN RODENTS
A CHOICE PROCEDURE TO ASSESS THE AVERSIVE EFFECTS OF DRUGS IN RODENTS
复制标题
DOI：
10.1901/jeab.2010.93-203
复制
发表时间：
2010-03-01
影响因子：
2.7
通讯作者：
Woods, James H.
中科院分区：
文献类型：
--
作者：
Podlesnik, Christopher A.;Jimenez-Gomez, Corina;Woods, James H.
这一系列实验的目的是开发一种操作性选择程序，以快速检查大鼠静脉注射药物的惩罚作用。首先，对实验者静脉注射组胺（一种已知的厌恶性药物）的心血管效应进行评估，以确定生物活性剂量范围。接下来，大鼠对两个杠杆中的每一个做出反应，同时提供固定比例1的食物强化时间表。当对其中一个选项做出反应时，静脉注射组胺沿着食物，并定期切换食物和组胺的控制杆。1.0 mg/kg/inj剂量的组胺对交替杠杆的运动反应有效，而生理盐水、0.1或0.3 mg/kg/inj组胺则无效。当组胺注射连续三次注射同一个杠杆时，组胺注射会产生可靠的替代杠杆选择，但当每次注射时在杠杆之间切换时，则不会产生可靠的选择。此外，组胺产生更大的选择时，它提出了更短的试验间隔时间的替代杠杆。这些结果表明，在适当的参数下，组胺和其他药物的厌恶作用可以通过同时选择程序迅速建立。
The goal of this series of experiments was to develop an operant choice procedure to examine rapidly the punishing effects of intravenous drugs in rats. First, the cardiovascular effects of experimenter-administered intravenous histamine, a known aversive drug, were assessed to determine a biologically active dose range. Next, rats responded oil each of two levers with concurrently available fixed-ratio 1 schedules of food reinforcement.. Intravenous histamine was delivered along with food when responses were made on one of the options, and the lever on which both food and histamine were contingent was switched on a regular basis. A dose of 1.0 mg/kg/inj of histamine was effective in moving responding to the alternate lever, whereas saline, 0.1, or 0.3 mg/kg/inj of histamine were not. Histamine injections produced reliable selection of the alternate lever when they were presented oil the same lever for three consecutive sessions, but not when they were switched between levers oil each session. In addition, histamine produced greater selection of the alternate lever when it was presented with shorter intertrial interval durations. These findings indicate that, with appropriate parameters, the aversive effects of histamine and perhaps other drugs call be established rapidly using a concurrent choice procedure.