Post-pubertal emergence of disrupted latent inhibition following prenatal immune activation
Post-pubertal emergence of disrupted latent inhibition following prenatal immune activation
复制标题
产前免疫激活后青春期后出现潜在抑制被破坏
DOI：
10.1007/s00213-003-1461-7
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发表时间：
2003
影响因子：
3.4
通讯作者：
I. Weiner
中科院分区：
文献类型：
--
作者：
L. Zuckerman;I. Weiner
有证据表明，产前感染与精神分裂症易感性增加之间存在关联，并且已经表明母体免疫反应，特别是促炎细胞因子的释放，可能会干扰正常的胎儿大脑发育。忽视无关刺激的能力受损被认为是精神分裂症的中枢缺陷之一，并表现为，除其他外，在中断潜伏抑制（LI）.ObjectivesTo测试产前免疫激活对LI在青少年和成年children.MethodsPregnant rats的影响注射合成细胞因子增强剂polyriboinosinic-polyribocytidilic acid（聚I：C，4 mg/kg）在妊娠第15天。LI进行了评估，在35天和3个月大的后代使用口渴的动机条件性情绪responseprocess. ResultsConsistently与精神分裂症的特征成熟延迟，产前免疫激活并没有影响LI的少年后代，但导致青春期后出现LI中断。此外，海马形态的显着改变类似于精神分裂症中发现的，是显而易见的在成年children.ConclusionsThese结果支持这一假设，即在怀孕期间的免疫激活可能会导致长期的异常模仿精神分裂症中观察到的。
RationaleThere is evidence pointing to an association between prenatal exposure to infection and increased liability to schizophrenia, and it has been suggested that the maternal immune response, in particular, the release of pro-inflammatory cytokines, may interfere with normal fetal brain development. Impaired capacity to ignore irrelevant stimuli is considered one of the central deficits in schizophrenia, and is manifested, among others, in disrupted latent inhibition (LI).ObjectivesTo test the effects of prenatal immune activation on LI in juvenile and adult offspring.MethodsPregnant rats were injected with the synthetic cytokine releaser polyriboinosinic-polyribocytidilic acid (poly I:C, 4 mg/kg) on gestational day 15. LI was assessed in 35-day and 3-month-old offspring using a thirst motivated conditioned emotional response procedure.ResultsConsistent with the characteristic maturational delay of schizophrenia, prenatal immune activation did not affect LI in the juvenile offspring but led to a post-pubertal emergence of LI disruption. In addition, pronounced alterations in hippocampal morphology resembling those found in schizophrenia, were evident in the adult offspring.ConclusionsThese results support the hypothesis that immune activation during pregnancy may lead to long-term abnormalities mimicking those observed in schizophrenia.
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DOI：
10.1073/pnas.93.17.9235
发表时间：
1996-08-20
影响因子：
11.1
作者：
Laruelle, M;Abi-Dargham, A;Innis, RB
通讯作者：
Innis, RB
DOI：
10.1176/ajp.155.6.761
发表时间：
1998-06
期刊：
The American journal of psychiatry
影响因子：
--
作者：
A. Abi-Dargham;R. Gil;J. Krystal;R. Baldwin;J. Seibyl;M. Bowers;C. Dyck;D. Charney;R. Innis;M. Laruelle
通讯作者：
A. Abi-Dargham;R. Gil;J. Krystal;R. Baldwin;J. Seibyl;M. Bowers;C. Dyck;D. Charney;R. Innis;M. Laruelle
影响因子：
--
作者：
MEDNICK, SA;MACHON, RA;BONETT, D
通讯作者：
BONETT, D
聚肌苷酸：聚胞苷酸是内皮细胞的有效激活剂。
DOI：
--
发表时间：
1994
期刊：
The American journal of pathology
影响因子：
--
作者：
Doukas,J;Cutler,AH;Mordes,JP
通讯作者：
Mordes,JP