Liver stem cells: Plasticity of the liver epithelium
Liver stem cells: Plasticity of the liver epithelium
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DOI：
10.3748/wjg.v25.i9.1037
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发表时间：
2019-03
影响因子：
4.3
通讯作者：
A. Tsuchiya;Wei-Yu Lu
中科院分区：
文献类型：
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作者：
A. Tsuchiya;Wei-Yu Lu
急性肝损伤后，肝脏具有很高的再生能力，但在慢性肝损伤时，这种再生能力往往受到损害。在慢性肝损伤期间，是否存在专门的肝干细胞群体作为再生的来源一直存在争议。转基因模型和细胞重编程的最新进展为研究肝上皮的可塑性提供了新的见解，并为未来治疗的发展指明了方向。本文将重点介绍有关肝损伤过程中再生的细胞来源以及促进肝再生的最新研究进展。
The liver has a high regenerative capacity after acute liver injury, but this is often impaired during chronic liver injury. The existence of a dedicated liver stem cell population that acts as a source of regeneration during chronic liver injury has been controversial. Recent advances in transgenic models and cellular reprogramming have provided new insights into the plasticity of the liver epithelium and directions for the development of future therapies. This article will highlight recent findings about the cellular source of regeneration during liver injury and the advances in promoting liver regeneration.