Short-term dietary selenium restriction in young adults: quantitative studies with the stable isotope 74SeO32−
Short-term dietary selenium restriction in young adults: quantitative studies with the stable isotope 74SeO32−
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年轻人短期膳食硒限制：稳定同位素 74SeO32− 的定量研究
DOI：
10.1079/bjn19840112
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发表时间：
1984
影响因子：
3.6
通讯作者：
M. Janghorbani
中科院分区：
文献类型：
--
作者：
L. J. Kasper;V. Young;M. Janghorbani
1.在四名年轻的成年男性北美居民中进行了45天的代谢研究，这些居民食用基于氨基酸混合物的受控饮食。在最初的10 d内，每日硒摄入量调整为107.7（SE 0.1）μg/d，在随后的35 d内，每日硒摄入量降至11.4（SE 0.1）μg/d。2.在研究的第4天和第39天，在吸收后状态下口服两剂稳定同位素（74 SeO 32-）。3.硒平衡（粪便+尿排泄）以及稳定同位素排泄的研究进行了整个45天期间，血浆和红细胞硒浓度也进行了监测。4.血浆硒浓度（μg/ml）从初始值0.132（SE 0.007）逐渐下降至研究结束时的0.083（SE 0.008）。红细胞中硒的浓度变化不一致（整个研究的平均值为0.147（SE 0.002）μg/ml）。5.粪便中未富集硒的排泄量从第1-10天的66（SE 6）μg/d下降到第14 ~ 40天的10.2（SE 0.8）μg/d。尿硒排泄量分别为43.9（SE 2.8）μg/d（第1-10天）和26.9（SE 4.6）μg/d（第14-40天）。未加硒的总平衡（摄入量-粪便排泄量-尿排泄量）为（μg/d）：-18（SE 7）d 10-19，-17（SE 2）d 19-39，-5（SE 1）d 38-45。6.在研究的硒充足和硒限制阶段，摄入标签的吸收分数分别为0.529（SE 0.032）和0.542（SE 0.038）。然而，吸收标记物的尿排泄从硒充足阶段第1天的6.57（SE 0.73）%降至硒限制阶段第1天的仅3.32（SE 0.26）%。在每个阶段的第7天也进行了类似的观察。7.这些结果表明，直接贡献摄入硒尿硒池是小的。
1. A 45 d metabolic study was carried out in four young adult male North American residents consuming a controlled diet based on an amino acid mixture. During the initial 10 d, total daily selenium intake was adjusted to 107.7 (SE 0.1) μg/d, which was reduced to 11.4 (SE 0.1) μg/d for the remaining 35 d. 2. Two doses of a stable isotope (74SeO32-) were administered orally in the post-absorptive state on days 4 and 39 of the study. 3. Se balance (faecal + urinary excretion) as well as stable isotope excretion studies were carried out for the entire 45 d period; blood plasma and erythrocyte Se concentrations were also monitored. 4. Plasma Se concentrations (μg/ml) fell progressively from the initial value of 0.132 (SE 0.007) to 0.083 (SE 0.008) at the end of the study. The erythrocyte concentrations of Se did not vary in a consistent manner (average value for the entire study 0.147 (SE 0.002) μg/ml). 5. Faecal excretion of unenriched Se decreased from 66 (SE 6) μg/d for days 1–10 to 10.2 (SE 0.8) μg/d for days 14–40. Mean urinary excretions of the unenriched Se were 43.9 (SE 2.8) μg/d (days 1–10) and 26.9 (SE 4.6) μg/d (days 14–40). Total balance (intake - faecal excretion - urinary excretion) for unenriched Se was μg/d):-18 (SE 7) days 10–19, -17 (SE 2) days 19–39, -5 (SE 1) days 38–45. 6. Fractional absorption of the ingested label was 0.529 (SE 0.032) and 0.542 (SE 0.038) for the Se-adequate and Se-restricted phases of the study. However, urinary excretion of the absorbed label was reduced from 6.57 (SE 0.73)% for day 1 of the Se-adequate phase to only 3.32 (SE 0.26)% for day 1 of the Se-restricted phase. Similar observations were also made for day 7 of each phase. 7. These findings indicate that immediate contribution of ingested Se to the urinary Se pool is small.
健康成人的硒代谢：使用稳定同位素 74SeO3(2-) 进行定量分析。
DOI：
10.1093/ajcn/35.4.647
发表时间：
1982
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Janghorbani,M;Christensen,MJ;Nahapetian,A;Young,VR
通讯作者：
Young,VR
硒的生物利用度参考人体营养。
DOI：
10.1093/ajcn/35.5.1076
发表时间：
1982
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Young,VR;Nahapetian,A;Janghorbani,M
通讯作者：
Janghorbani,M
硒稳定同位素在人类代谢研究中的应用：分析方法的发展。
DOI：
10.1093/ajcn/34.12.2816
发表时间：
1981
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Janghorbani,M;Ting,BT;Young,VR
通讯作者：
Young,VR