Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.
Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.
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DOI：
10.1161/atvbaha.116.306926
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Aikawa M
中科院分区：
文献类型：
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作者：
Nakano T;Fukuda D;Koga J;Aikawa M
Notch信号通路调节各种细胞类型和器官的发育，也参与了成人的疾病机制。越来越多的证据表明，它在心血管和代谢性疾病中扮演着重要角色。Notch信号组件也控制免疫细胞的表型。Notch途径的Delta样配体4(DLL4)在体外和体内促进巨噬细胞的促炎活性。DLL4阻断可减轻小鼠的慢性动脉粥样硬化、静脉移植物疾病、血管钙化、胰岛素抵抗和脂肪肝。因此，DLL4-Notch轴可能参与心脏代谢紊乱的共同机制，成为改善这些全球健康问题的潜在治疗靶点。
The Notch signaling pathway regulates the development of various cell types and organs, and also contributes to disease mechanisms in adults. Accumulating evidence suggests its role in cardiovascular and metabolic diseases. Notch signaling components also control the phenotype of immune cells. Delta-like ligand 4 (Dll4) of the Notch pathway promotes pro-inflammatory activation of macrophages in vitro and in vivo. Dll4 blockade attenuates chronic atherosclerosis, vein graft disease, vascular calcification, insulin resistance and fatty liver in mice. The Dll4-Notch axis may thus participate in the shared mechanisms for cardiometabolic disorders, serving as a potential therapeutic target for ameliorating these global health problems.