Interleukin-2 Production by Peripheral Blood Mononuclear Cells from Patients with Myasthenia gravis
Interleukin-2 Production by Peripheral Blood Mononuclear Cells from Patients with Myasthenia gravis
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DOI：
10.1159/000069079
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发表时间：
2003-03
影响因子：
2.4
通讯作者：
K. Utsugisawa;Y. Nagane;D. Obara;R. Kondoh;H. Yonezawa;H. Tohgi
中科院分区：
文献类型：
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作者：
K. Utsugisawa;Y. Nagane;D. Obara;R. Kondoh;H. Yonezawa;H. Tohgi
我们检测了75例未经治疗的重症肌无力（MG）患者和48例对照患者的植物血凝素（PHA）刺激的外周血单个核细胞（PBMs）产生白细胞介素-2（IL-2）。MG患者包括PBM IL-2产生升高的患者（> 1，250 pg/ml;对照组的平均值± 2SD）（n = 29，39%）和PBM IL-2产生正常的患者（<1，250 pg/ml）（n = 46，61%）。PBM IL-2产生升高的患者的显著特征包括血清抗乙酰胆碱受体抗体水平升高、严重的全身症状、胸腺增生和胸腺切除术的显著效果（p < 0.05）。这些结果表明，PBM IL-2产生的升高可以反映某些MG患者T细胞功能的异常，PBM IL-2产生应被视为治疗的候选靶点。
We examined interleukin-2 (IL-2) production by phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMs) from 75 untreated myasthenia gravis (MG) patients and 48 control patients. Patients with MG consisted of those with elevated PBM IL-2 production (>1,250 pg/ml; mean + 2SD of the controls) (n = 29, 39%) and those with normal PBM IL-2 production (<1,250 pg/ml) (n = 46, 61%). Significant characteristics of patients with elevated PBM IL-2 production included elevated serum levels of anti-acetylcholine receptor antibodies, severe generalized symptoms, thymic hyperplasia, and marked effects of thymectomy (p < 0.05). These findings suggest that elevated PBM IL-2 production can reflect functional abnormalities of T cells in some patients with MG, and that PBM IL-2 production should be considered as a candidate target of therapy.