Altered serum levels of TNF-α, IL-6, and IL-18 in depressive disorder patients
Altered serum levels of TNF-α, IL-6, and IL-18 in depressive disorder patients
复制标题
抑郁症患者血清 TNF-α、IL-6 和 IL-18 水平发生变化
DOI：
10.1002/hup.2588
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发表时间：
2017-07-01
影响因子：
1.7
通讯作者：
He, Hongbo
中科院分区：
文献类型：
--
作者：
Fan, Ni;Luo, Yayan;He, Hongbo
目的：抑郁症与细胞因子水平的异常变化有关。本研究旨在评估抑郁症患者血清中肿瘤坏死因子 (TNF) α、白细胞介素 (IL) 6 和 IL-18 的浓度。还评估了这三种细胞因子浓度与患者临床特征之间的相关性。方法：使用酶联免疫吸附测定法评估 64 名抑郁症患者和 80 名健康对照受试者的血清 TNF-α、IL-6 和 IL-18 浓度。使用汉密尔顿抑郁量表17评估患者的抑郁症状。结果：与对照组相比，抑郁患者血清TNF-α和IL-6浓度升高，但IL-18浓度降低。 TNF-α 和 IL-6 浓度与抑郁症患者的汉密尔顿抑郁量表 17 评分显着正相关。结论：这些发现提供了额外的证据，表明 TNF-α、IL-6 和 IL-18 活性的改变可能有助于抑郁症的病理生理学。
Objective: Depressive disorder is associated with abnormal changes in cytokines levels. This study aimed to assess serum concentrations of tumor necrosis factor (TNF) alpha, interleukin (IL) 6, and IL-18 in depressive patients. The correlations between these three cytokine concentrations and the patients' clinical characteristics were also assessed.Methods: Serum TNF-alpha, IL-6, and IL-18 concentrations were assessed using enzyme-linked immunosorbent assay from 64 depressive patients and 80 healthy control subjects. Depressive symptoms of patients were assessed using Hamilton Depression Scale-17.Results: Depressive patients had increased serum TNF-alpha and IL-6 concentrations but decreased IL-18 concentrations than controls. TNF-alpha and IL-6 concentrations were significantly positively associated with Hamilton Depression Scale-17 scores in depressive patients.Conclusion: These findings provided additional evidence that altered TNF-alpha, IL-6, and IL-18 activities may contribute to the pathophysiology of depressive disorder.