Creation of single molecular conjugates of metal?organic cages and DNA
Creation of single molecular conjugates of metal?organic cages and DNA
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金属有机笼和 DNA 的单分子缀合物的创建
DOI：
10.1039/d3cc00460k
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发表时间：
2023
影响因子：
4.9
通讯作者：
Matsuda Ryotaro
中科院分区：
文献类型：
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作者：
Nakajo Toshinobu;Kusaka Shinpei;Hiraoka Haruka;Nomura Kohei;Matsubara Noriaki;Baba Rintaro;Yoshida Yuki;Nakamoto Kosuke;Honma Masakazu;Iguchi Hiroaki;Uchihashi Takayuki;Abe Hiroshi;Matsuda Ryotaro
在这里，我们报道了一种金属-有机笼子(MOC)和DNA(MOC-DNA)等摩尔共轭的发展。几个MOC-DNA偶联物通过与具有互补碱基序列的模板DNA配位而组装成程序化结构。此外，与MOC的结合极大地提高了DNA通过脂质双层的渗透性，呈现出作为药物输送系统的巨大潜力。
Here we report the development of an equimolar conjugate of a metal–organic cage (MOC) and DNA (MOC-DNA). Several MOC-DNA conjugates were assembled into a programmed structure by coordinating with a template DNA having a complementary base sequence. Moreover, conjugation with the MOC drastically enhanced the permeability of DNA through the lipid bilayer, presenting great potential as a drug delivery system.