A convenient synthesis and the asymmetric hydrogenation of N-phthaloyl dehydroamino acid esters.
A convenient synthesis and the asymmetric hydrogenation of N-phthaloyl dehydroamino acid esters.
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DOI：
10.1021/ol800996j
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发表时间：
2008-06
期刊：
影响因子：
5.2
通讯作者：
Jian Chen;Qiang Liu;Weicheng Zhang;Stephen Spinella;A. Lei;Xumu Zhang
中科院分区：
文献类型：
--
作者：
Jian Chen;Qiang Liu;Weicheng Zhang;Stephen Spinella;A. Lei;Xumu Zhang
报道了一种简便的方法，以易得的溴代乙烯基（或对甲苯磺酸乙烯基）和邻苯二甲酰亚胺钾为原料合成N-邻苯二甲酰脱氢氨基酸酯。铑催化的不对称氢化这些底物与TangPhos得到的产品具有良好的对映选择性（高达99%ee）。
A convenient synthetic method was reported for the preparation of N-phthaloyl dehydroamino acid esters from easily accessible vinyl bromides (or vinyl tosylate) and potassium phthalimide. Rh-catalyzed asymmetric hydrogenation of these substrates with TangPhos gave the products with good to excellent enantioselectivities (up to 99% ee).