Increase of Circulating B7-H4-Expressing CD68+ Macrophage Correlated With Clinical Stage of Lung Carcinomas
Increase of Circulating B7-H4-Expressing CD68+ Macrophage Correlated With Clinical Stage of Lung Carcinomas
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DOI：
10.1097/cji.0b013e31824212c4
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发表时间：
2012-05-01
影响因子：
3.9
通讯作者：
Huang, Jian-An
中科院分区：
文献类型：
--
作者：
Chen, Cheng;Zhu, Yi-Bei;Huang, Jian-An
肿瘤相关巨噬细胞（TAM）在肿瘤进展过程中影响多种过程，如血管生成、肿瘤细胞增殖和转移。在多种肿瘤类型中，TAM的量与预后相关，但它们在肺癌中的作用尚未完全阐明。本研究的目的是研究B7-H4表达TAM在一系列的56例肺癌。在外周血中，比较了肺癌患者、结核患者和健康供体中表达B7-H4的巨噬细胞（CD 68（+）细胞）。肺癌患者外周血中表达B7-H4的巨噬细胞显著高于健康人和肺结核患者。表达B7-H4的巨噬细胞与肿瘤大小、淋巴结转移和TNM分期有关。根据文献资料，认为肺癌增加了表达B7-H4的巨噬细胞，这可能有利于肿瘤的进展。
Tumor-associated macrophages (TAM) influence diverse processes such as angiogenesis, tumor cell proliferation, and metastasis during tumor progression. In a variety of tumor types, the amount of TAM has been associated with prognosis, but their role in lung cancer has not been fully elucidated. The purpose of this study was to investigate the B7-H4-expressing TAM in a series of 56 cases of lung carcinoma. In peripheral blood, B7-H4-expressing macrophage (CD68(+) cells) was compared among patients with lung cancer, patients with tuberculosis, and healthy donors. B7-H4-expressing macrophage in peripheral blood from lung cancer patients was significantly higher than that from healthy donors and tuberculosis patients. B7-H4-expressing macrophage was thereafter related to tumor size, lymph node metastasis and TNM stage. On the basis of the data obtained from literature, it is suggestd that lung carcinomas increase B7-H4-expressing macrophages, which might favor tumor progression.