beta fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction - The ECTIM study
beta fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction - The ECTIM study
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DOI：
10.1161/01.cir.93.3.440
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发表时间：
1996-02-01
期刊：
影响因子：
37.8
通讯作者：
Cambien, F
中科院分区：
文献类型：
--
作者：
Behague, I;Poirier, O;Cambien, F
纤维蛋白原基因的多态性已被证明影响血浆纤维蛋白原水平和外周动脉疾病的风险。我们现在提出了一个详细的分析结果，β纤维蛋白原基因与血浆纤维蛋白原和冠状动脉疾病（CAD）的严重程度，在心肌梗死（MI）患者在ECTIM Study.Methods和结果10多态性的β纤维蛋白原基因，包括5个新的多态性鉴定的单链构象多态性分析，对565例心肌梗死患者和668例正常对照者进行了α纤维蛋白原基因3'侧翼区的多态性分析。这些多态性在MI患者和对照组中处于紧密连锁不平衡，基因型频率相似。在多变量分析中，只有两个多态性，β Hae III（P
Background Polymorphisms of the beta fibrinogen gene have been shown to affect plasma fibrinogen levels and the risk of peripheral arterial disease. We now present the results of a detailed analysis of the beta fibrinogen gene in relation to plasma fibrinogen and to the severity of coronary artery disease (CAD) in patients with myocardial infarction (MI) in the ECTIM Study.Methods and Results Ten polymorphisms of the beta fibrinogen gene, including five new polymorphisms identified by single-strand conformation polymorphism analysis, and one polymorphism in the 3' flanking region of the alpha fibrinogen gene were investigated in 565 patients with MI and 668 control subjects. The polymorphisms were in tight linkage disequilibrium and the genotype frequencies were similar in patients with MI and control subjects. In the multivariate analysis, only two polymorphisms, beta Hae III (P