Accuracy and feasibility of cone-beam computed tomography for stereotactic radiosurgery setup
Accuracy and feasibility of cone-beam computed tomography for stereotactic radiosurgery setup
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DOI：
10.1118/1.2731031
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发表时间：
2007-06-01
期刊：
影响因子：
3.8
通讯作者：
Gutin, Philip H.
中科院分区：
文献类型：
--
作者：
Chang, Jenghwa;Yenice, Kamil M.;Gutin, Philip H.
研究了锥束计算机断层扫描（CBCT）在立体定向放射外科（SRS）中的图像融合、目标定位和设置精度。采用刚性附着在立体定向Brown-Roberts-Wells （BRW）框架上的随机头部幻影，研究了CBCT的几何精度。从传统的模拟CT中测量嵌入头部幻影中的多个无线电不透明目标对之间的距离和角间距，为几何精度分析提供了比较数据。通过对四个圆柱形物体（直径9毫米，长度25毫米）的BRW定位分析，研究了CBCT扫描的定位精度。通过对CBCT和常规CT扫描的多个模拟目标进行BRW定位，定量评价图像融合精度。最后，提出了立体定向放射外科治疗的CBCT设置程序，并利用正交靶验证成像评估了其准确性。我们的研究表明，CBCT没有表现出任何明显的几何畸变。4个圆柱形物体的立体定向坐标与常规CT的平均误差为0.30 mm，标准差为0.09 mm。CBCT与常规CT的平均配准精度为0.28 mm （SD=0.10 mm）。我们提出的CBCT设置程序的设置不确定度与文献中报道的传统基于框架的立体定向系统的设置不确定度相同（平均值=1.34 mm， SD=0.33 mm）。综上所述，CBCT可用于指导SRS治疗设置，其准确性可与目前使用的基于框架的立体定向放射外科系统相媲美，前提是患者在治疗过程中不能运动。(c) 2007年美国医学物理学家协会。
Image fusion, target localization, and setup accuracy of cone-beam computed tomography (CBCT) for stereotactic radiosurgery (SRS) were investigated in this study. A Rando head phantom rigidly attached to a stereotactic Brown-Roberts-Wells (BRW) frame was utilized to study the geometric accuracy of CBCT. Measurements of distances and angular separations between selected pairs of multiple radio-opaque targets embedded in the head phantom from a conventional simulation CT provided comparative data for geometric accuracy analysis. Localization accuracy of the CBCT scan was investigated from an analysis of BRW localization of four cylindrical objects (9 rum in diameter and 25 mm in length) independently computed from CBCT and conventional CT scans. Image fusion accuracy was quantitatively evaluated from BRW localization of multiple simulated targets from the CBCT and conventional CT scan. Finally, a CBCT setup procedure for stereotactic radiosurgery treatments was proposed and its accuracy was assessed using orthogonal target verification imaging. Our study showed that CBCT did not present any significant geometric distortions. Stereotactic coordinates of the four cylindrical objects as determined from the CBCT differed from those determined from the conventional CT on average by 0.30 mm with a standard deviation (SD) of 0.09 mm. The mean image registration accuracy of CBCT with conventional CT was 0.28 mm (SD=0.10 mm). Setup uncertainty of our proposed CBCT setup procedure was on the same order as the conventional framed-based stereotactic systems reported in the literature (mean =1.34 mm, SD=0.33 mm). In conclusion, CBCT can be used to guide SRS treatment setup with accuracy comparable to the currently used frame-based stereotactic radiosurgery systems provided that intra-treatment patient motion is prevented. (c) 2007 American Association of Physicists in Medicine.