Body Mass Index, Waist Circumference, and the Clustering of Cardiometabolic Risk Factors in Early Childhood
Body Mass Index, Waist Circumference, and the Clustering of Cardiometabolic Risk Factors in Early Childhood
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DOI：
10.1111/ppe.12268
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发表时间：
2016-03-01
影响因子：
2.8
通讯作者：
Birken, Catherine S.
中科院分区：
文献类型：
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作者：
Anderson, Laura N.;Lebovic, Gerald;Birken, Catherine S.
背景肥胖起源于儿童早期，然而，有有限的证据表明人体测量指标和幼儿心脏代谢危险因素之间的关联。我们的目的是评估身体质量指数（BMI）和腰围（WC）之间的协会在有关心脏代谢危险因素，并探讨这些factors.MethodsA横断面研究进行了1-5岁的儿童通过TARGetKids！（n=2917）。Logistic回归分析用于评估BMI和WC z评分与个体传统和可能的非传统心脏代谢危险因素之间的相关性。这些措施的潜在聚类进行了评估，使用主成分分析（PCA）。结果儿童肥胖（BMI Z-评分>2）与高（>第90百分位）瘦素[比值比（OR）8.15，95%置信区间（CI）4.56，14.58]和胰岛素（OR=1.76; 95%CI 1.05，2.94）。WC z评分>1与高胰岛素（OR 1.59，95% CI 1.11，2.28）、瘦素（OR 5.48，95% CI 3.48，8.63）和25-羟基维生素D相关
BackgroundObesity has its origins in early childhood; however, there is limited evidence of the association between anthropometric indicators and cardiometabolic risk factors in young children. Our aim was to evaluate the associations between body mass index (BMI) and waist circumference (WC) in relation to cardiometabolic risk factors and to explore the clustering of these factors.MethodsA cross-sectional study was conducted in children aged 1-5 years through TARGetKids! (n=2917). Logistic regression was used to evaluate associations between BMI and WC z-scores and individual traditional and possible non-traditional cardiometabolic risk factors. The underlying clustering of these measures was evaluated using principal components analysis (PCA).ResultsChild obesity (BMI z-score >2) was associated with high (>90th percentile) leptin [odds ratio (OR) 8.15, 95% confidence interval (CI) 4.56, 14.58] and insulin (OR=1.76; 95% CI 1.05, 2.94). WC z-score >1 was associated with high insulin (OR 1.59, 95% CI 1.11, 2.28), leptin (OR 5.48, 95% CI 3.48, 8.63) and 25-hydroxyvitamin D