Human hepatic stem cell and maturational liver lineage biology.
Human hepatic stem cell and maturational liver lineage biology.
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DOI：
10.1002/hep.24157
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发表时间：
2011-03
期刊：
影响因子：
13.5
通讯作者：
Reid, Lola M.
中科院分区：
文献类型：
--
作者：
Turner, Rachael;Lozoya, Oswaldo;Wang, Yunfang;Cardinale, Vincenzo;Gaudio, Eugenio;Alpini, Gianfranco;Mendel, Gemma;Wauthier, Eliane;Barbier, Claire;Alvaro, Domenico;Reid, Lola M.
肝脏由成熟的细胞谱系组成，这些细胞起源于肝外靠近十二指肠的肝胰总管和肝内由门静脉三联体组成的1区。肝外干细胞壁龛是位于胆管壁深处的胆管周围腺；肝内的是出生后肝脏的肝灵管，起源于胎儿肝脏的导管板。在肝内，至少有8个成熟谱系阶段，从1区（门静脉周围）的干细胞到中腺区（2区），再到3区中心周围发现的最成熟的细胞和凋亡细胞。在胆道树中发现的仍在定义中。实质细胞与间充质细胞谱系密切相关，它们的成熟是协调的。每个谱系阶段由实质细胞和间充质细胞伴侣组成，通过形态、倍性、抗原、生化特征、基因表达和分裂能力来区分。它们受染色质变化（如甲基化）、旁分泌信号梯度（可溶性因子和不溶性细胞外基质成分）、机械力和来自晚期谱系细胞的反馈回路信号的控制。反馈环路信号由谱系晚期细胞分泌到胆汁中，流回门静脉周围区，调节干细胞和其他谱系早期细胞，在决定肝脏肿块大小的机制中。对成熟谱系生物学及其由这些多种机制调控的认识为肝脏生物学、病理和再生医学策略提供了新的认识。
Livers are comprised of maturational lineages of cells beginning extrahepatically in the hepato-pancreatic common duct near the duodenum and intrahepatically in zone 1 by the portal triads. The extrahepatic stem cell niches are the peribiliary glands deep within the walls of the bile ducts; those intrahepatically are the canals of Hering in postnatal livers and that derive from ductal plates in fetal livers. Intrahepatically, there are at least 8 maturational lineage stages from the stem cells in zone 1 (periportal), through the midacinar region (zone 2), to the most mature cells and apoptotic cells found pericentrally in zone 3. Those found in the biliary tree are still being defined. Parenchymal cells are closely associated with lineages of mesenchymal cells, and their maturation is coordinated. Each lineage stage consists of parenchymal and mesenchymal cell partners distinguishable by their morphology, ploidy, antigens, biochemical traits, gene expression, and ability to divide. They are governed by changes in chromatin (e.g. methylation), gradients of paracrine signals (soluble factors and insoluble extracellular matrix components), mechanical forces, and feedback loop signals derived from late lineage cells. Feedback loop signals, secreted by late lineage stage cells into bile, flow back to the periportal area and regulate the stem cells and other early lineage stage cells, in mechanisms dictating the size of the liver mass. Recognition of maturational lineage biology and its regulation by these multiple mechanisms offers new understandings of liver biology, pathologies, and strategies for regenerative medicine.
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影响因子：
2
作者：
Cohen, MM
通讯作者：
Cohen, MM
影响因子：
4.8
作者：
Jhandier, MN;Kruglov, EA;Dranoff, JA
通讯作者：
Dranoff, JA
影响因子：
29.4
作者：
Crosby, HA;Kelly, DA;Strain, AJ
通讯作者：
Strain, AJ
DOI：
10.1152/ajpgi.1999.276.5.g1289
发表时间：
1999-05-01
影响因子：
4.5
作者：
LeSage, GD;Glaser, SS;Alpini, G
通讯作者：
Alpini, G
影响因子：
15.9
作者：
Alvaro, D;Alpini, G;Benedetti, A
通讯作者：
Benedetti, A