PMUT:: a web-based tool for the annotation of pathological mutations on proteins
PMUT:: a web-based tool for the annotation of pathological mutations on proteins
复制标题
DOI：
10.1093/bioinformatics/bti486
复制
发表时间：
2005-07-15
期刊：
影响因子：
5.8
通讯作者：
Orozco, M
中科院分区：
文献类型：
--
作者：
Ferrer-Costa, C;Gelpí, JL;Orozco, M
PMUT允许基于神经网络的使用对单点氨基酸突变的病理特征进行快速和准确的预测（类似于在人类中80%的成功率）。该程序还允许快速扫描突变热点，这些热点通过三个程序获得：（1）丙氨酸扫描，（2）大规模突变和（3）遗传可及突变。蛋白质数据库（PDB）结构的图形界面（如果可用）和包含所有非冗余PDB结构的热点配置文件的数据库也可从PMUT服务器访问。
PMUT allows the fast and accurate prediction (similar to 80% success rate in humans) of the pathological character of single point amino acidic mutations based on the use of neural networks. The program also allows the fast scanning of mutational hot spots, which are obtained by three procedures: ( 1) alanine scanning, ( 2) massive mutation and ( 3) genetically accessible mutations. A graphical interface for Protein Data Bank ( PDB) structures, when available, and a database containing hot spot profiles for all non-redundant PDB structures are also accessible from the PMUT server.