Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation
Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation
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DOI：
10.1046/j.1365-2249.1996.36742.x
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发表时间：
1996-06-01
影响因子：
4.6
通讯作者：
Mestecky, J
中科院分区：
文献类型：
--
作者：
Kutteh, WH;Prince, SJ;Mestecky, J
人类宫颈产生的免疫球蛋白A的数量和亚类分布可能对防御性传播疾病以及调节生育能力产生重大影响。取15例正常排卵妇女排卵前后宫颈粘液。采用酶联免疫吸附试验(EL ISA)法检测血清总IgA(包括IgA1和IgA2)、免疫球蛋白(Ig G)和免疫球蛋白M(IgM)。宫颈粘液中均检出较高水平的IGA。每日尿黄体生成素测定确定排卵时，排卵前2~3天IEA产量最高。宫颈粘液中可检测到等量的IgA1和IgA2，其中80%的IgA以聚合体形式存在。人宫颈分泌液中的IgA水平、IgA1/IgA2比值的升高，以及聚合型IgA的优势，提示宫颈分泌物中的大部分IgA来源于当地生产。
The quantity and subclass distribution of IgA produced by the human uterine cervix may have a significant impact on the defence against sexually transmitted diseases as well as the regulation of fertility. Cervical mucus was obtained from 15 normal ovulating women around the time of ovalation. The total amounts of secreted IgA (including IgA1 and IgA2), IgG, and IgM were determined bf ELISA. IgA was detected at high levels in all samples of cervical mucus. When ovulation was ascertained by daily urinary luteinizing hormone testing, IEA production was maximal 2-3 days before ovulation. Equal proportions of IgA1 and IgA2 were detected in cervical mucus, and 80% of the IgA occurred in the polymeric forms. The increased levels of IgA, the ratios of IgA1 to IgA2, and the predominance of polymeric IgA indicate that much of the IgA in human uterine cervical fluid originates from local production.