l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
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DOI：
10.1111/j.1349-7006.2008.00969.x
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发表时间：
2008-12-01
期刊：
影响因子：
5.7
通讯作者：
Mori, Masatomo
中科院分区：
文献类型：
--
作者：
Kaira, Kyoichi;Oriuchi, Noboru;Mori, Masatomo
L型氨基酸转运蛋白（LAT）1表达在人类肿瘤转移过程中的意义尚不清楚，而实验研究表明LAT1与癌细胞的转移过程相关。我们比较了 93 名癌症患者的原发部位和一致肺转移部位之间 LAT1 和 CD98 的免疫组织化学表达，所有患者均接受过开胸手术。通过免疫组织化学染色分析 93 例癌症患者的切除肿瘤中的 LAT1、CD98、Ki-67 标记指数、血管内皮生长因子 (VEGF)、CD31 和 CD34：45 例结肠癌；九种乳腺癌；八种头颈癌； 11种生殖器癌症； 14 软组织肉瘤；和其他六种癌症。这些标记物在转移部位的表达显着高于原发部位。总体而言，原发部位的 LAT1、CD98、Ki-67、VEGF、CD31 和 CD34 的阳性率分别为 40%、24%、56%、41%、45% 和 39%，转移部位的阳性率分别为 65%、45%、84%、67%、73% 和 61%。 LAT1表达与CD98表达、血管生成和细胞增殖密切相关。 LAT1 和 CD98 表达之间的关联在原发部位和转移部位最强。本研究表明，LAT1 和 CD98 的过度表达在多种人类肿瘤的转移过程中发挥着重要作用。此外，LAT1表达与细胞增殖和血管生成显着相关。 （癌症科学 2008 年；99：2380-2386）。
The significance of l-type amino acid transporter (LAT) 1 expression remains unclear in the metastatic process of human neoplasms, whereas experimental studies have demonstrated that LAT1 is associated with the metastatic process of cancer cells. We compared the immunohistochemical expression of LAT1 and CD98 between the primary site and a concordant pulmonary metastatic site in 93 cancer patients, all of whom had undergone thoracotomy. LAT1, CD98, Ki-67 labeling index, vascular endothelial growth factor (VEGF), CD31, and CD34 were analyzed by immunohistochemical staining in the resected tumors of 93 cancer patients: 45 colon cancers; nine breast cancers; eight head and neck cancers; 11 genital cancers; 14 soft-tissue sarcomas; and six other cancers. The expression of these markers was significantly higher in the metastatic sites than in the primary sites. In total, the positive rates of LAT1, CD98, Ki-67, VEGF, CD31, and CD34 were 40, 24, 56, 41, 45, and 39%, respectively, in the primary sites and 65, 45, 84, 67, 73, and 61%, respectively, in the metastatic sites. LAT1 expression was closely correlated with CD98 expression, angiogenesis, and cell proliferation. The association between LAT1 and CD98 expression was strongest in the primary and metastatic sites. The present study suggests that overexpression of LAT1 and CD98 has an important role to play in the metastatic process of variable human neoplasms. Moreover, LAT1 expression was significantly correlated with cell proliferation and angiogenesis. (Cancer Sci 2008; 99: 2380-2386).