A large-scale study of bone marrow involvement in patients with Hodgkin's lymphoma.
A large-scale study of bone marrow involvement in patients with Hodgkin's lymphoma.
复制标题
霍奇金淋巴瘤患者骨髓受累的大规模研究。
DOI：
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
E. Gallo
中科院分区：
文献类型：
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作者：
A. Levis;D. Pietrasanta;L. Godio;U. Vitolo;G. Ciravegna;F. Di Vito;P. Gavarotti;T. Guglielmelli;L. Orsucci;E. Raviolo;D. Rota Scalabrini;F. Salvi;A. Tonso;M. Aglietta;M. Boccadoro;A. Gallamini;G. Saglio;E. Scassa;E. Gallo
本研究旨在确定可以预测霍奇金淋巴瘤（HL）骨髓受累（BMI）的变量，并分析双侧骨髓环钻活检（BMB）相对于单侧骨髓环钻活检（BMB）的益处。从1982年至2000年，在参与皮埃蒙特霍奇金病登记研究的机构随访的1161例HL患者中，在诊断时进行了BMB。616例患者（53%）接受了双侧BMB，其余545例患者（47%）接受了单侧BMB。BMB结果和其他临床特征之间的关系进行了回顾性研究，单因素和多因素分析。92例患者（8%）显示BMI：其中51例分期为双侧BMB，41例为单侧BMB。在92例BMI患者中，仅25例（27%）出现第二次结节受累。在多变量分析中，预测BMI的5个独立因素是B症状、淋巴管下受累、混合细胞（MC）和淋巴细胞耗竭（LD）组织学、≥ 4个淋巴区受累和肝脏受累。根据这些变量的存在，BMI的概率分布如下：0、1、2和≥ 3个因素阳性的患者分别为0.3%、2.5%、7.6%和27%。在51例双侧BMB分期患者中，33例（65%）在两个标本中均显示BMI，而其余18例（35%）仅限于2个标本中的1个。基于5个变量的评分可以预测BMI的概率，评分为0且BMI概率<0.5%的患者可以避免BMB。当需要进行骨肌活检时，双侧活检优于单侧活检。
This study was designed to identify variables that can predict bone marrow involvement (BMI) in Hodgkin's lymphoma (HL), and to analyze the benefit of bilateral over unilateral bone marrow trephine biopsy (BMB). From 1982 to 2000, BMB had been performed at diagnosis in 1161 patients with HL who had been followed from the institutions participating in the Piemonte Hodgkin's Disease Registry. Six hundred and sixteen patients (53%) had received bilateral BMB, and the remaining 545 patients (47%) received unilateral BMB. The relationships between BMB results and other clinical features were retrospectively studied with both univariate and multivariate analyses. Ninety-two patients (8%) showed BMI: 51 of them were staged with bilateral and 41 with unilateral BMB. Among the 92 patients with BMI, a second extranodal involvement was present in only 25 patients (27%). In multivariate analysis, the 5 independent factors that predicted for BMI were B symptoms, infradiaphragmatic involvement, mixed cellularity (MC) and lymphocyte depleted (LD) histology, involvement of > or = 4 lymphatic areas, and liver involvement. The probability of BMI according to the presence of these variables was distributed as follows: 0.3%, 2.5%, 7.6%, and 27% in patients positive for 0, 1, 2, and > or = 3 factors, respectively. Among 51 patients staged with bilateral BMB, BMI was shown in both specimens in 33 cases (65%), whereas the positivity was limited to only 1 of the 2 specimens in the remaining 18 cases (35%). A score based on 5 variables can predict the probability of BMI, and BMB could be avoided in patients with a score of 0 and a probability of BMI of < 0.5%. When BMB is needed, the superiority of bilateral over unilateral biopsy is suggested.
影响因子：
11.2
作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana
通讯作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana
使用磁共振成像检测淋巴瘤累及骨髓。
DOI：
10.1200/jco.1987.5.2.225
发表时间：
1987
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
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作者：
Shields,AF;Porter,BA;Churchley,S;Olson,DO;Appelbaum,FR;Thomas,ED
通讯作者：
Thomas,ED