Roles of D1 and D2 dopamine receptor subtypes in mediating the methamphetamine-induced changes in monoamine systems.
Roles of D1 and D2 dopamine receptor subtypes in mediating the methamphetamine-induced changes in monoamine systems.
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发表时间：
1986-09
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通讯作者：
P. Sonsalla;J. Gibb;G. Hanson
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作者：
P. Sonsalla;J. Gibb;G. Hanson
先前的研究表明，甲基苯丙胺对多巴胺能和血清素能系统的影响可能与甲基苯丙胺诱导的多巴胺释放增加有关。氟哌啶醇能够预防甲基苯丙胺的这些作用，这表明多巴胺受体的激活参与了甲基苯丙胺作用的调节。目前的研究是为了确定多巴胺受体亚型在甲基苯丙胺效应中可能发挥的作用。我们发现D1拮抗剂SCH23390能减弱或阻断甲基苯丙胺对多巴胺能和血清素能系统的作用，而D2拮抗剂舒必利只能阻断甲基苯丙胺对多巴胺能系统的作用。本研究结果表明，甲基苯丙胺诱导多巴胺能作用于D1和D2受体的增加与甲基苯丙胺对多巴胺能系统的影响有关。相反，多巴胺作用于D1受体，而不作用于D2受体，似乎与冰毒对新纹状体和大脑皮层的血清素能系统的影响有关。
Previous studies have demonstrated that the effects of methamphetamine (METH) on dopaminergic and serotonergic systems are likely related to METH-induced increases in dopamine release. The ability of haloperidol to prevent these effects of METH suggests that dopamine receptor activation is involved in mediating these METH actions. The present studies were undertaken to determine what role the dopamine receptor subtype(s) might have in such METH effects. We found that the D1 antagonist, SCH23390, attenuated or blocked the effects of METH on dopaminergic and serotonergic systems, whereas the D2 antagonist, sulpiride, blocked the effects of METH on only the dopaminergic system. The results of the present studies suggest that METH-induced increases in dopaminergic action on both D1 and D2 receptors are associated with the effects of METH on the dopaminergic system. In contrast, dopamine action on D1, but not on D2, receptors appears to be involved in the effects of METH on the serotonergic systems of the neostriatum and the cerebral cortex.