Usefulness of N-terminal pro-brain natriuretic peptide as a biomarker of the presence of carcinoid heart disease
Usefulness of N-terminal pro-brain natriuretic peptide as a biomarker of the presence of carcinoid heart disease
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DOI：
10.1016/j.amjcard.2008.05.047
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发表时间：
2008-10-01
影响因子：
2.8
通讯作者：
Davar, Joseph
中科院分区：
文献类型：
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作者：
Bhattacharyya, Sanjeev;Toumpanakis, Christos;Davar, Joseph
我们试图调查是否N-末端脑利钠肽前体（NT-pro-BNP）可以作为一个生物标志物检测类癌性心脏病（CHD）; 200例类癌综合征患者进行了筛选CHD经胸超声心动图。制定类癌评分以量化CHD的严重程度。所有患者术前均检测NT-pro-BNP。将患者分类为纽约心脏协会分级。冠心病39例（19.5%）。CHD患者NT-pro-BNP水平（中位数1,149 pg/ml）显著高于非CHD患者（中位数101 pg/ml，p
We sought to investigate whether N-terminal pro-brain natriuretic peptide (NT-pro-BNP) can be used as a biomarker for the detection of carcinoid heart disease (CHD); 200 patients with carcinoid syndrome were screened for CHD using transthoracic echocardiography. A carcinoid score was formulated to quantify severity of CHD. NT-pro-BNP was measured in all patients before echocardiography. Patients were categorised into New York Heart Association class. CHD was present in 39 patients (19.5%). NT-pro-BNP was significantly higher in those with CHD (median 1,149 pg/ml) than in those without CHD (median 101 pg/ml, p