Differential roles of insulin receptor in adipocyte progenitor cells in mice.
Differential roles of insulin receptor in adipocyte progenitor cells in mice.
复制标题
胰岛素受体在小鼠脂肪细胞祖细胞中的不同作用。
DOI：
10.1016/j.mce.2023.111968
复制
发表时间：
2023
影响因子：
4.1
通讯作者：
Jiang,Yuwei
中科院分区：
文献类型：
--
作者：
Yuan,Yexian;Shi,Zuoxiao;Xiong,Shaolei;Hu,Ruoci;Song,Qing;Song,Zhenyuan;Ong,Sang-Ging;Jiang,Yuwei
白色脂肪组织（WAT）的发育发生在不同的胚胎和出生后阶段，并随后在整个生命中维持。然而，在不同阶段负责WAT发展的具体介质和机制尚不清楚。在这项研究中，我们研究了胰岛素受体（IR）在WAT发育和稳态过程中调节脂肪细胞祖细胞（APCs）脂肪生成和脂肪细胞功能的作用。我们使用两种体内脂肪谱系追踪和删除系统，分别在胚胎apc和成年apc中删除IR，以探索小鼠WAT发育和WAT稳态过程中IR的具体需求。我们的数据表明，apc中的IR表达可能不是成人脂肪细胞分化所必需的，但似乎对脂肪组织发育至关重要。我们揭示了在WAT发育和体内平衡过程中，IR在APCs中的不同作用。
The development of white adipose tissue (WAT) occurs during distinct embryonic and postnatal stages, and it is subsequently maintained throughout life. However, the specific mediators and mechanisms responsible for WAT development during different phases remain unclear. In this study, we investigate the role of the insulin receptor (IR) in regulating adipogenesis and adipocyte function within adipocyte progenitor cells (APCs) during WAT development and homeostasis. We use twoin vivoadipose lineage tracking and deletion systems to delete IR either in embryonic APCs or adult APCs, respectively, to explore the specific requirements of IR during WAT development and WAT homeostasis in mice. Our data suggest that IR expression in APCs may not be essential for adult adipocyte differentiation but appears to be crucial for adipose tissue development. We reveal a surprising divergent role of IR in APCs during WAT development and homeostasis.