Independent developmental programs for two estrogen-regulated genes.

Independent developmental programs for two estrogen-regulated genes.
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DOI：
10.1126/science.6740331
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发表时间：
1984-08
期刊：
Science
影响因子：
56.9
通讯作者：
A. Elbrecht;C. Lazier;A. Protter;D. Williams
A. Elbrecht;C. Lazier;A. Protter;D. Williams
中科院分区：
综合性期刊1区
文献类型：
--
作者：
A. Elbrecht;C. Lazier;A. Protter;D. Williams

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鸡胚发生过程中肝脏载脂蛋白II和卵黄原蛋白II信使RNA的测定表明，这些基因在不同发育阶段具有雌激素反应性。过量互补DNA的敏感溶液杂交实验表明，载脂蛋白II转录本在第9天被诱导到每个细胞500分子，而卵黄蛋白原II信使RNA的诱导直到第11天才被发现。因此，两个雌激素调节基因在成人中具有共同的功能和协调的调节，可能是独立的发育程序。
Measurement of hepatic apolipoprotein II and vitellogenin II messenger RNA during chicken embryogenesis showed that these genes acquire estrogen responsiveness at different stages of development. Sensitive solution hybridization assays with excess complementary DNA showed that apolipoprotein II transcripts were induced to 500 molecules per cell at day 9, whereas induction of vitellogenin II messenger RNA was not found until day 11. Thus, two estrogen regulated genes of common function and coordinately regulated in the adult may be on independent developmental programs.