Fibroblast-matrix interactions and their role in the pathogenesis of fibrosis.
Fibroblast-matrix interactions and their role in the pathogenesis of fibrosis.
复制标题
成纤维细胞-基质相互作用及其在纤维化发病机制中的作用。
DOI：
--
复制
发表时间：
1990
影响因子：
2.3
通讯作者：
T. Kreig
中科院分区：
文献类型：
--
作者：
C. Mauch;T. Kreig
细胞外基质具有复杂的结构，为结缔组织提供支架，并影响许多细胞功能。成纤维细胞的附着、趋化和增殖依赖于细胞与细胞外基质的不同成分的相互作用。此外，包括蛋白质和胶原合成在内的生物合成活动由成纤维细胞与周围基质的二维或三维接触来调节。由于硬皮病的特点是受累器官中的胶原过度沉积，因此许多人试图在分子水平上定义细胞代谢的改变。本文就成纤维细胞基质相互作用在调控成纤维细胞生理过程中的功能及其在纤维化中的激活作用作一综述。
The extracellular matrix has a complex structure which provides the scaffold of the connective tissue and influences many cellular functions. Fibroblast attachment, chemotaxis, and proliferation depend on the interaction of the cells with different components of the extracellular matrix. In addition, biosynthetic activities including protein and collagen synthesis are regulated by a two- or three-dimensional contact of fibroblasts with the surrounding matrix. Since scleroderma is characterized by an excessive deposition of collagen in the involved organs, many attempts have been made to define the altered cellular metabolism on a molecular level. This review summarized the role of fibroblast matrix interaction for the control of fibroblast functions during physiological processes and their activation in fibrosis.