Automation synthesis modules review
Automation synthesis modules review
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DOI：
10.1016/j.apradiso.2012.09.010
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发表时间：
2013-06-01
影响因子：
1.6
通讯作者：
Marengo, M.
中科院分区：
文献类型：
--
作者：
Boschi, S.;Lodi, F.;Marengo, M.
Ga-68标记示踪剂的引入改变了神经内分泌肿瘤的诊断方法，可靠的长寿命Ge-68/Ga-68发生器的可用性是Ga-68放射性药物开发的基础。临床需求的巨大增长，监管问题的影响以及操作人员的仔细辐射防护促进了生产过程的广泛自动化。沿着讨论了Ga-68放射化学自动化系统的发展、不同的工程和软件策略以及放射性同位素的后处理，以及自动化与法规的影响。(C)2012爱思唯尔有限公司保留所有权利。
The introduction of Ga-68 labelled tracers has changed the diagnostic approach to neuroendocrine tumours and the availability of a reliable, long-lived Ge-68/Ga-68 generator has been at the bases of the development of Ga-68 radiopharmacy. The huge increase in clinical demand, the impact of regulatory issues and a careful radioprotection of the operators have boosted for extensive automation of the production process. The development of automated systems for Ga-68 radiochemistry, different engineering and software strategies and post-processing of the eluate were discussed along with impact of automation with regulations. (C) 2012 Elsevier Ltd. All rights reserved.