Reactivation or transformation? Motor memory consolidation associated with cerebral activation time-locked to sleep spindles.
Reactivation or transformation? Motor memory consolidation associated with cerebral activation time-locked to sleep spindles.
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DOI：
10.1371/journal.pone.0174755
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Doyon J
中科院分区：
文献类型：
--
作者：
Fogel S;Albouy G;King BR;Lungu O;Vien C;Bore A;Pinsard B;Benali H;Carrier J;Doyon J
运动记忆的巩固被认为依赖于在学习过程中招募的大脑区域的睡眠依赖性重新激活。然而，到目前为止，还没有直接的证据支持人类的这种说法，支持这种重新激活的生理过程也是未知的。在这里，同时进行脑电图和功能磁共振成像（EEG-fMRI）记录在学习后的睡眠，直接调查运动序列学习（MSL）过程中形成的记忆痕迹的纺锤体相关的再激活，其关系到一夜之间的性能增强（反映巩固）。我们发现，在MSL任务训练期间招募的纹状体-小脑-皮质网络内的大脑区域，特别是纹状体，在睡眠期间也被激活，时间锁定为纺锤波。有趣的是，巩固的痕迹，在纹状体不是简单地加强，但转换/重组从rostrodoral（联想）到caudoventral（感觉运动）亚区。此外，重新激活的程度与一夜之间的表现改善相关。总之，目前的研究结果表明，纹状体再激活与睡眠纺锤波在学习后的夜晚，与运动记忆巩固。
Motor memory consolidation is thought to depend on sleep-dependent reactivation of brain areas recruited during learning. However, up to this point, there has been no direct evidence to support this assertion in humans, and the physiological processes supporting such reactivation are unknown. Here, simultaneous electroencephalographic and functional magnetic resonance imaging (EEG-fMRI) recordings were conducted during post-learning sleep to directly investigate the spindle-related reactivation of a memory trace formed during motor sequence learning (MSL), and its relationship to overnight enhancement in performance (reflecting consolidation). We show that brain regions within the striato-cerebello-cortical network recruited during training on the MSL task, and in particular the striatum, were also activated during sleep, time-locked to spindles. Interestingly, the consolidated trace in the striatum was not simply strengthened, but was transformed/reorganized from rostrodorsal (associative) to caudoventral (sensorimotor) subregions. Moreover, the degree of the reactivation was correlated with overnight improvements in performance. Altogether, the present findings demonstrate that striatal reactivation linked to sleep spindles in the post-learning night, is related to motor memory consolidation.