DNA synthesis studies in pre-meiotic mouse oogenesis.
DNA synthesis studies in pre-meiotic mouse oogenesis.
复制标题
减数分裂前小鼠卵子发生中的 DNA 合成研究。
DOI：
10.1016/0014-4827(86)90068-6
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发表时间：
1986
影响因子：
3.7
通讯作者：
Jagiello,G
中科院分区：
文献类型：
--
作者：
Sung,WK;Van'tHof,J;Jagiello,G
DNA纤维放射自显影被用于小鼠卵子发生，以测试Callan的假说，即较长的S期的结果减少的数量的活性起始位点。这些数据表明，在小鼠卵子发生的S期的持续时间的减数分裂前增加的特点是快速的初始速率的链增长和较大的复制子的大小相比，复制小鼠体细胞的DNA。这些发现与小鼠精子发生中的结果不同，也不支持激活位点抑制的Callan假说。
DNA fiber autoradiography was used in mouse oogenesis to test Callan's hypothesis that a longer S phase results from a reduction in the number of active initiation sites. The data indicated that the premeiotic increase in the duration of S phase in mouse oogenesis was characterized by a rapid initial rate of chain growth and a larger replicon size when compared with replicating DNA of somatic mouse cells. These findings were at variance with those in mouse spermatogenesis and also did not support the Callan hypothesis of activation site repression.