B cell memory: understanding COVID-19.

B cell memory: understanding COVID-19.
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DOI:
10.1016/j.immuni.2021.01.014
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发表时间:
2021-02-09
期刊:
影响因子:
32.4
通讯作者:
Tarlinton D
Tarlinton D
中科院分区:
医学1区
文献类型:
--
作者:
Quast I;Tarlinton D

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免疫记忆是一种保护我们免受再次感染的机制。由B细胞产生的抗体是这种防御策略的组成部分,并且是几乎所有疫苗成功的基础。在这里,我们解释了B细胞记忆是如何通过感染和疫苗接种产生的,是什么影响了它的疗效和持久性,以及如何在对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的免疫反应中表征这些参数将有助于通过疫苗接种实现保护性免疫。免疫记忆是一种保护我们免受再次感染的机制。由B细胞产生的抗体是这种防御策略的组成部分,并且是几乎所有疫苗成功的基础。在这里,我们解释了B细胞记忆是如何通过感染和疫苗接种产生的,是什么影响了它的疗效和持久性,以及如何在对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的免疫反应中表征这些参数将有助于通过疫苗接种实现保护性免疫。
Immunological memory is a mechanism to protect us against reinfection. Antibodies produced by B cells are integral to this defense strategy and underlie virtually all vaccine success. Here, we explain how B cell memory is generated by infection and vaccination, what influences its efficacy and its persistence, and how characterizing these parameters in the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will help achieve protective immunity through vaccination. Immunological memory is a mechanism to protect us against reinfection. Antibodies produced by B cells are integral to this defense strategy and underlie virtually all vaccine success. Here, we explain how B cell memory is generated by infection and vaccination, what influences its efficacy and its persistence, and how characterizing these parameters in the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will help achieve protective immunity through vaccination.
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