Meta-analysis study of glutathione-S-transferases (GSTM1, GSTP1, and GSTT1) gene polymorphisms and risk of acute myeloid leukemia
Meta-analysis study of glutathione-S-transferases (GSTM1, GSTP1, and GSTT1) gene polymorphisms and risk of acute myeloid leukemia
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DOI：
10.1080/10428190903003236
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发表时间：
2009-01-01
影响因子：
2.6
通讯作者：
Bammidi, Vamsee K.
中科院分区：
文献类型：
--
作者：
Das, Prabhavathy;Shaik, Abjal Pasha;Bammidi, Vamsee K.
为了研究谷胱甘肽-S-转移酶（GST）多态性与急性髓细胞白血病（AML）风险的相关性，对1998年至2009年发表的病例对照研究进行了荟萃分析。采用固定效应和随机效应模型评估合并优势比（OR）。计算研究间的异质性，并构建漏斗图以检验发表偏倚。GSTM 1缺失基因型、GSTP 1 Val 105等位基因和GSTT 1缺失基因型的OR值分别为1.30（95%置信区间（CI）1.04-1.62，p = 0.018）、1.03（95% CI 0.80-1.33，p = 0.80）和1.24（95% CI 0.98-1.58，p = 0.06）。在统计学上，观察到GSTM 1显著增加AML风险，而GSTT 1缺失基因型观察到临界显著性。固定效应模型显示GSTM 1和GSTT 1缺失基因型的AML发病风险显著（p < 0.05）。在与GSTP 1相关的研究之间发现了显著异质性（p = 0.162），然而，在评估GSTM 1（Q值= 44; I-2 = 70.9; p值< 0.01）和GSTT 1（Q值= 26.03; I-2 = 57.74; p值< 0.01）多态性的研究中没有观察到异质性。从有限的研究GST 1与AML的风险，该基因的作用不能完全确定。这三个基因与AML风险的显著相关性必须在人口、吸烟、饮食习惯、种族和人种方面进一步评估。
To investigate the association of glutathione-S-transferase (GST) polymorphisms with the risk of acute myeloid leukemia (AML), a meta-analysis of case-control studies published between 1998 and 2009 was performed. Pooled odds ratios (ORs) were assessed using both fixed- and random-effects models. Heterogeneity across studies was calculated, and funnel plots were constructed to test for publication bias. Overall, the random-effects OR with GSTM1 null genotype, GSTP1 Val105 allele and GSTT1 null genotype were 1.30 (95% confidence intervals (CI) 1.04-1.62, p = 0.018), 1.03 (95% CI 0.80-1.33, p = 0.80) and 1.24 (95% CI 0.98-1.58, p = 0.06), respectively. Statistically, significant increased risk of AML was observed with GSTM1 while borderline significance was seen with GSTT1 null genotypes. However, fixed- effects model showed significant risk of AML in the presence of null genotypes of GSTM1 and GSTT1(p < 0.05). Significant heterogeneity was found between studies relating to GSTP1 (p = 0.162), however, no heterogeneity was seen in studies that evaluated GSTM1 (Q-value = 44; I-2 = 70.9; p-value < 0.01]; and GSTT1 (Q-value = 26.03; I-2 = 57.74; p-value < 0.01] polymorphisms. From the limited studies on the association of GSTP1 with risk of AML, the role of this gene cannot be ascertained fully. Significant association of these three genes with risk of AML must be evaluated further with respect to population, smoking, eating habits, ethnicity, and race.