SYNTHESIS AND STRUCTURE OF AN IRON(III) SULFIDE-FERRITIN BIOINORGANIC NANOCOMPOSITE
SYNTHESIS AND STRUCTURE OF AN IRON(III) SULFIDE-FERRITIN BIOINORGANIC NANOCOMPOSITE
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DOI：
10.1126/science.269.5220.54
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发表时间：
1995-07-07
期刊：
影响因子：
56.9
通讯作者：
MANN, S
中科院分区：
文献类型：
--
作者：
DOUGLAS, T;DICKSON, DPE;MANN, S
在马脾铁蛋白纳米腔内原位合成了每簇含500或3000个铁原子的无定形硫化铁矿物。铁-57穆斯堡尔光谱表明，在3000个铁原子簇中，大多数铁原子是三价的，而在500个铁原子簇中，大约50%的铁原子是Fe(III)，其余原子的有效氧化态约为+2.5。500-铁原子纳米复合材料的铁k边扩展x射线吸收精细结构数据与边缘共享的FeS4四面体的无序排列一致，这些四面体由Fe(S)(2)Fe桥连接，其键长与铁硫簇的立方体型基序相似。本文所采用的控制合成生物无机纳米复合材料的方法可用于具有生物相容性和生物活性的分散材料的纳米工程。
Amorphous iron sulfide minerals containing either 500 or 3000 iron atoms in each cluster have been synthesized in situ within the nanodimensional cavity of horse spleen ferritin. Iron-57 Mossbauer spectroscopy indicated that most of the iron atoms in the 3000-iron atom cores are trivalent, whereas in the 500-iron atom clusters, approximately 50 percent of the iron atoms are Fe(III), with the remaining atoms having an effective oxidation state of about +2.5. Iron K-edge extended x-ray absorption fine structure data for the 500-iron atom nanocomposite are consistent with a disordered array of edge-shared FeS4 tetrahedra, connected by Fe(S)(2)Fe bridges with bond lengths similar to those of the cubane-type motif of iron-sulfur clusters. The approach used here for the controlled synthesis of bioinorganic nanocomposites could be useful for the nanoscale engineering of dispersed materials with biocompatible and bioactive properties.