Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning?
Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning?
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过敏性婴儿肠道微生物群的异常组成：断奶后双歧杆菌疗法的目标？
DOI：
10.1136/gut.51.1.51
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发表时间：
2002-07-01
期刊：
影响因子：
24.5
通讯作者：
Isolauri, E
中科院分区：
文献类型：
--
作者：
Kirjavainen, PV;Arvola, T;Isolauri, E
背景：最近的研究表明肠道菌群的组成与过敏性炎症之间存在一定的关系，并证实了益生菌对这种炎症的下调作用。目的：我们的目的是描述肠道微生物与过敏致敏程度之间的关系，并评估补充双歧杆菌治疗过敏的疗效是否与肠道微生物群的调节有关。方法：这项随机研究纳入了21例早发型特应性湿疹患儿，其中8例对广泛水解乳清配方奶粉（EHF）不耐受（高敏化组（HSG））， 13例对广泛水解乳清配方奶粉（EHF）耐受（敏化组（SG））。在SG中，6例断奶至不添加EHF（安慰剂组（PG））， 7例断奶至添加乳酸双歧杆菌b-12的EHF（双歧杆菌治疗组（BbG））。HSG组仅在断奶前对婴儿的粪便微生物群进行分析，而SG组在断奶前后对婴儿的粪便微生物群进行分析。结果：HSG组婴儿乳酸菌/肠球菌数量高于SG组。血清总IgE浓度与所有婴儿的大肠杆菌计数和HSG中的拟杆菌计数直接相关，表明这些细菌的存在与特应性致敏的程度有关。在断奶期间，补充的效果表现为大肠杆菌数量的减少和对拟杆菌数量增加的保护。结论：这些数据表明，补充双歧杆菌似乎以一种可能减轻过敏性炎症的方式改变肠道微生物群。需要进一步的研究来证实这一结论。
Background: Recent data have outlined a relationship between the composition of the intestinal microflora and allergic inflammation, and demonstrated the competence of probiotics in downregulation of such inflammation.Aims: Our aims were to characterise the relationship between gut microbes and the extent of allergic sensitisation and to assess whether the efficacy of bifidobacterial supplementation in the treatment of allergy could relate to modulation of the intestinal microbiota.Methods: This randomised study included 21 infants with early onset atopic eczema of whom eight were intolerant (highly sensitised group (HSG)) and 13 tolerant (sensitised group (SG)) to extensively hydrolysed whey formula (EHF). In the SG, six were weaned to EHF without (placebo group (PG)) and seven to EHF with Bifidobacterium lactis Bb-12 supplementation (bifidobacteria treated group (BbG)). The faecal microflora of infants in the HSG was analysed only before weaning whereas in the SG the faecal microflora was analysed both before and after weaning.Results: Infants in the HSG had greater numbers of lactobacilli/enterococci than those in the SG. Serum total IgE concentration correlated directly with Escherichia coli counts in all infants and with bacteroides counts in the HSG, indicating that the presence of these bacteria is associated with the extent of atopic sensitisation. The effect of supplementation was characterised as a decrease in the numbers of Escherichia coli and protection against an increase in bacteroides numbers during weaning.Conclusions: These data indicate that bifidobacterial supplementation appears to modify the gut microbiota in a manner that may alleviate allergic inflammation. Further studies are needed to confirm this conclusion.