Do community-level predictors of pneumococcal carriage continue to play a role in the conjugate vaccine era?
Do community-level predictors of pneumococcal carriage continue to play a role in the conjugate vaccine era?
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在结合疫苗时代，社区层面的肺炎球菌携带预测因子是否继续发挥作用？
DOI：
10.1017/s0950268813000794
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发表时间：
2013
影响因子：
4.2
通讯作者：
Huang,SS
中科院分区：
文献类型：
--
作者：
Hsu,KK;Rifas-Shiman,SL;Shea,KM;Kleinman,KP;Lee,GM;Lakoma,M;Pelton,SI;Finkelstein,JA;Huang,SS
本文研究了在七价肺炎球菌结合疫苗（PCV 7）时代，以前确定的社区因素（拥挤的家庭和/或贫困线以下的人的比例高）是否仍然与儿童肺炎球菌携带有关。使用逻辑回归，使用个体因素来开发基础模型，在其中添加社区水平因素，以评估对来自马萨诸塞州（波士顿城区，波士顿郊外）的两个儿科研究队列中肺炎球菌携带的影响。在普及儿童PCV 7疫苗接种六年后，我们没有发现一致的证据表明人口普查区的特征（例如，人口规模和密度、年龄和种族分布、参与集体育儿的百分比、父母教育、缺乏单位内管道的百分比、贫困和社区稳定性）在加入个体预测因素时影响肺炎球菌携带的几率。（例如，年龄较小、当前呼吸道感染和参加集体保育）。在免疫覆盖率不断提高的时代，社区因素如何影响肺炎球菌携带继续发生变化。
This paper examined whether previously identified community-level factors (high proportion of crowded households and/or persons below the poverty level) remained associated with childhood pneumococcal carriage in the heptavalent pneumococcal conjugate vaccine (PCV7) era. Using logistic regression, individual factors were used to develop base models to which community-level factors were added to evaluate impact on pneumococcal carriage within two paediatric study cohorts from Massachusetts (urban Boston, outside Boston). Six years after introduction of universal childhood PCV7 vaccination, we found no consistent evidence that census tract characteristics (e.g. population size and density, age and race distribution, percent participating in group childcare, parental education, percent lacking in-unit plumbing, poverty, and community stability) affected odds of pneumococcal carriage when added to individual predictors (e.g. younger age, current respiratory tract infections, and attendance in group childcare). How community-level factors influence pneumococcal carriage continues to change in the era of increasing immunization coverage.