Brain targeting and glomerulus formation of two olfactory neuron populations expressing related receptor types
Brain targeting and glomerulus formation of two olfactory neuron populations expressing related receptor types
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DOI：
10.1046/j.0953-816x.2001.01788.x
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发表时间：
2001-11-01
影响因子：
3.4
通讯作者：
Strotmann, J
中科院分区：
文献类型：
--
作者：
Conzelmann, S;Malun, D;Strotmann, J
表达mOR37气味受体亚家族不同成员的嗅觉感觉神经元将其轴突发送到位于嗅球附近的不同肾小球[Strotmann， J., Conzelmann， S., Beck， A., Feinstein， P., Breer， H. & Mombaerts， P. (2000) J.神经科学。[j].中国农业科学，2016,29(6):627 - 638。在这项研究中，利用转基因小鼠系的潜力来探索表达不同mOR37亚型的两个神经元群体的受体表达的开始，轴突的生长以及肾小球的形成。数据表明，这两个神经元群的这些特征在时间上是同步的。从15岁到出生那天，两个mOR37种群的轴突终止于假定的嗅球的一个共同的小区域。在出生后的短时间内，两个轴突群分离成不同的原肾小球结构；在此期间仍可观察到一些异常纤维。
Olfactory sensory neurons expressing different members of the mOR37 odourant receptor subfamily send their axons to distinct glomeruli located in the immediate vicinity in the olfactory bulb [Strotmann, J., Conzelmann, S., Beck, A., Feinstein, P., Breer, H. & Mombaerts, P. (2000) J. Neurosci., 20, 6927-6938]. In this study, the potential of transgenic mouse lines was used to explore the onset of receptor expression, the outgrowth of axons as well as the glomerulus formation for two neuron populations expressing different mOR37 subtypes. The data indicate a synchronous time course of these features for both neuron populations. From E15 until the day of birth, the axons of the two mOR37 populations terminate in a common, small area of the presumptive olfactory bulb. During a short postnatal phase, the two axon populations segregate into distinct, protoglomerular structures; some aberrant fibers can still be observed during this period.