The 1918 influenza pandemic: Insights for the 21st century
The 1918 influenza pandemic: Insights for the 21st century
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DOI：
10.1086/511989
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发表时间：
2007-04-01
影响因子：
6.4
通讯作者：
Fauci, Anthony S.
中科院分区：
文献类型：
--
作者：
Morens, David M.;Fauci, Anthony S.
1918年至1919年的H1N1流感大流行是人类历史上最致命的事件之一，估计造成5000万至1亿人死亡。由于最近的H5N1禽流感流行与零星的人类死亡有关，因此人们担心可能会出现与1918年大流行一样致命或更致命的新大流行。因此，了解1918年的事件和经历是非常重要的。然而，尽管对1918年病毒的整个基因组进行了基因测序，关于1918年大流行的许多问题仍然存在。在这篇综述中，我们讨论了其中的几个问题，涉及大流行病毒的起源，不寻常的流行病学特征，以及死亡的原因和人口统计学模式。这些问题都无法得到充分的回答，这表明需要继续保持对大流行的警惕，进行基础和应用研究，并制定大流行防范计划，强调预防、控制、抗病毒药物治疗和医院重症监护。
The 1918-1919 H1N1 influenza pandemic was among the most deadly events in recorded human history, killing an estimated 50-100 million persons. Because recent H5N1 avian epizootics have been associated with sporadic human fatalities, concern has been raised that a new pandemic, as fatal as the pandemic of 1918, or more so, could be developing. Understanding the events and experiences of 1918 is thus of great importance. However, despite the genetic sequencing of the entire genome of the 1918 virus, many questions about the 1918 pandemic remain. In this review we address several of these questions, concerning pandemic-virus origin, unusual epidemiologic features, and the causes and demographic patterns of fatality. That none of these questions can yet be fully answered points to the need for continued pandemic vigilance, basic and applied research, and pandemic preparedness planning that emphasizes prevention, containment, and treatment with antiviral medications and hospital-based intensive care.